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Published VersionCC BY V4.0, Open Access
Journal article
Retinal thickness in healthy Australian Aboriginal and Torres Strait Islander children
PLoS One, Vol.17(8), pp.1-13
2022
PMID: 36040965
Abstract
Background:
Understanding normative retinal thickness characteristics is critical for diagnosis and monitoring of pathology, particularly in those predisposed to retinal disease. The macular retinal layer thickness of Australian Aboriginal and/or Torres Strait Islander children was examined using spectral-domain optical coherence tomography.
Methods:
High-resolution macular optical coherence tomography imaging was performed on 100 Aboriginal and/or Torres Strait Islander children and 150 non-Indigenous visually healthy children aged 4–18 years. The imaging protocol included a 6-line radial scan centred on the fovea. Images were segmented using semi-automated software to derive thickness of the total retina, inner and outer retina, and individual retinal layers across the macular region. Repeated measures ANOVAs examined variations in thickness associated with retinal region, age, gender and Indigenous status.
Results:
Retinal thickness showed significant topographical variations (p < 0.01), being thinnest in the foveal zone, and thickest in the parafovea. The retina of Aboriginal and/or Torres Strait Islander children was significantly thinner than non-Indigenous children in the foveal (p < 0.001), parafoveal (p = 0.002), and perifoveal zones (p = 0.01), with the greatest difference in the foveal zone (mean difference: 14.2 μm). Inner retinal thickness was also thinner in Aboriginal and/or Torres Strait Islander children compared to non-Indigenous children in the parafoveal zone (p < 0.001), and outer retinal thickness was thinner in the foveal (p < 0.001) and perifoveal zone (p < 0.001). Retinal thickness was also significantly greater in males than females (p < 0.001) and showed a statistically significant positive association with age (p = 0.01).
Conclusion:
There are significant differences in macular retinal thickness between Aboriginal and/or Torres Strait Islander children and non-Indigenous children, which has implications for interpreting optical coherence tomography data and may relate to risk of macula disease in this population.
Details
- Title
- Retinal thickness in healthy Australian Aboriginal and Torres Strait Islander children
- Authors
- Rebecca A. Cox (Author) - Queensland University of TechnologyScott A. Read (Corresponding Author) - Queensland University of TechnologyShelley Hopkins (Author) - Queensland University of TechnologyDavid Alonso-Caneiro (Author) - Queensland University of TechnologyJoanne M. Wood (Author) - Queensland University of Technology
- Publication details
- PLoS One, Vol.17(8), pp.1-13
- Publisher
- Public Library of Science
- Date published
- 2022
- DOI
- 10.1371/journal.pone.0273863
- ISSN
- 1932-6203
- PMID
- 36040965
- Copyright note
- © 2022 Cox et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Grant note
- QUT Faculty of Health Pilot Project Grant (SAR, JMW, SH), IHBI Vision and Eye Health Research Development Grant (SAR, JMW, SH), The Australian Government Research Training Stipend (RAC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973595402621
- Output Type
- Journal article
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- Ophthalmology
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