Retinal Differential Light Sensitivity Variation Across the Macula in Healthy Subjects: Importance of Cone Separation and Loci Eccentricity

Danuta M. Sampson; Danial Roshandel; Avenell L. Chew; Yufei Wang; Paul G. Stevenson; Matthew N. Cooper; Elaine Ong; Lawrence Wong; Jonathan La; David Alonso-Caneiro; Enid Chelva; Jane C. Khan; David D. Sampson; Fred K. Chen

doi:10.1167/tvst.10.6.16

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Retinal Differential Light Sensitivity Variation Across the Macula in Healthy Subjects: Importance of Cone Separation and Loci Eccentricity

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Retinal Differential Light Sensitivity Variation Across the Macula in Healthy Subjects: Importance of Cone Separation and Loci Eccentricity

Danuta M. Sampson, Danial Roshandel, Avenell L. Chew, Yufei Wang, Paul G. Stevenson, Matthew N. Cooper, Elaine Ong, Lawrence Wong, Jonathan La, David Alonso-Caneiro, …

Translational Vision Science & Technology, Vol.10(6), pp.1-16

2021

DOI: https://doi.org/10.1167/tvst.10.6.16

PMID: 34111262

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Abstract

photoreceptors

adaptive optics retinal imaging

microperimetry

retinal structure-function structure

normative data

Purpose: Microperimetry measures differential light sensitivity (DLS) at specific retinal locations. The aim of this study is to examine the variation in DLS across the macula and the contribution to this variation of cone distribution metrics and retinal eccentricity. Methods: Forty healthy eyes of 40 subjects were examined by microperimetry (MAIA) and adaptive optics imaging (rtxl). Retinal DLS was measured using the grid patterns: foveal (2 degrees-3 degrees), macular (3 degrees-7 degrees), and meridional (2 degrees-8 degrees on horizontal and vertical meridians). Cone density (CD), distribution regularity, and intercone distance (ICD) were calculated at the respective test loci coordinates. Linear mixed-effects regression was used to examine the association between cone distribution metrics and loci eccentricity, and retinal DLS. Results: An eccentricity-dependent reduction in DLS was observed on all MAIA grids, which was greatest at the foveal-parafoveal junction (2 degrees-3 degrees) (-0.58 dB per degree, 95% confidence interval [CI]; -0.91 to -0.24 dB, P < 0.01). Retinal DLS across the meridional grid changed significantly with each 1000 cells/deg(2) change in CD (0.85 dB, 95% CI; 0.10 to 1.61 dB, P = 0.03), but not with each arcmin change in ICD (1.36 dB, 95% CI; -2.93 to 0.20 dB, P = 0.09). Conclusions: We demonstrate significant variation in DLS across the macula. Topographical change in cone separation is an important determinant of the variation in DLS at the foveal-parafoveal junction. We caution the extrapolation of changes in DLS measurements to cone distribution because the relationship between these variables is complex. Translational Relevance: Cone density is an independent determinant of DLS in the foveal-parafoveal junction in healthy eyes.

Details

Title: Retinal Differential Light Sensitivity Variation Across the Macula in Healthy Subjects: Importance of Cone Separation and Loci Eccentricity
Authors: Danuta M. Sampson (Author) - The University of Western Australia
Danial Roshandel (Author) - The University of Western Australia
Avenell L. Chew (Author) - The University of Western Australia
Yufei Wang (Author) - University of Wisconsin–Madison
Paul G. Stevenson (Author) - The Kids Research Institute Australia
Matthew N. Cooper (Author) - The Kids Research Institute Australia
Elaine Ong (Author) - The University of Western Australia
Lawrence Wong (Author) - The University of Western Australia
Jonathan La (Author) - The University of Western Australia
David Alonso-Caneiro (Author) - The University of Western Australia
Enid Chelva (Author) - Sir Charles Gairdner Hospital
Jane C. Khan (Author) - The University of Western Australia
David D. Sampson (Author) - University of Surrey
Fred K. Chen (Corresponding Author) - The University of Western Australia
Publication details: Translational Vision Science & Technology, Vol.10(6), pp.1-16
Publisher: Association for Research in Vision and Ophthalmology
Date published: 2021
DOI: 10.1167/tvst.10.6.16
ISSN: 2164-2591
PMID: 34111262
Copyright note: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
Grant note: Ophthalmic Research Institute of Australia APP1142962 / National Health and Medical Research Council McCusker Charitable Foundation University of Western Australia Postgraduate Award Telethon Perth Children's Hospital Research Fund Bayer Global Ophthalmology Awards Program
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 99972395302621
Output Type: Journal article

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Web Of Science research areas: Ophthalmology

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