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Brain and Behavior - 2024 - Mitchell - Resting‐State Electroencephalogram Complexity Is Associated With Oral Ketamine1.18 MB
Published VersionCC BY V4.0, Open Access
Journal article
Resting‐State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response: A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale Entropy
Brain and Behavior, Vol.14(11), pp.1-16
2024
PMID: 39607091
Appears in Thompson Institute Research Collection
Abstract
Introduction
Subanesthetic doses of ketamine are a promising novel treatment for suicidality; however, the evidence for predictive biomarkers is sparse. Recently, measures of complexity, including Lempel–Ziv complexity (LZC) and multiscale entropy (MSE), have been implicated in ketamine's therapeutic action. We evaluated electroencephalogram (EEG)-derived LZC and MSE differences between responders and nonresponders to oral ketamine treatment.
Methods
A total of 31 participants received six single, weekly (titrated) doses of oral racemic ketamine (0.5–3 mg/kg) and underwent EEG scans at baseline (Week 0), post-treatment (Week 6), and follow-up (Week 10). Resting-state (eyes closed and open) recordings were processed in EEGLAB, and complexity metrics were extracted using the Neurokit2 package. Participants were designated responders or nonresponders by clinical response (Beck Suicide Scale [BSS] score reduction of ≥ 50% from baseline to the respective timepoint or score ≤ 6) and then compared in terms of complexity across resting-state conditions and time.
Results
Employing a Bayesian mixed effects model, we found strong evidence that LZC was higher in the eyes-open compared to eyes-closed condition, as were MSE scales 1–3. At a global level, responders displayed elevated eyes-open baseline complexity compared to nonresponders, with these values decreasing from baseline to post-treatment (Week 6) in responders only. Exploratory analyses revealed that the elevated baseline eyes-open LZC in responders was spatially localized to the left frontal lobe (F1, AF3, FC1, and F3).
Conclusion
EEG-complexity metrics may be sensitive biomarkers for evaluating and predicting oral ketamine treatment response, with the left prefrontal cortex bein a possible treatment response region.
Details
- Title
- Resting‐State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response: A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale Entropy
- Authors
- Jules S. Mitchell (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson InstituteToomas E. Anijärv - University of the Sunshine Coast, Queensland, Thompson InstituteAdem T. Can - University of the Sunshine Coast, Queensland, Thompson InstituteMegan Dutton - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel F. Hermens - University of the Sunshine Coast, Queensland, Thompson InstituteJim Lagopoulos - Thompson Brain and Mind Healthcare (Australia)
- Publication details
- Brain and Behavior, Vol.14(11), pp.1-16; 16
- Publisher
- John Wiley & Sons Ltd.
- Date published
- 2024
- DOI
- 10.1002/brb3.70166
- ISSN
- 2162-3279
- PMID
- 39607091
- Copyright note
- © 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Data Availability
- Research data are not shared.
- Grant note
- This study was supported by the Australian Government Research Training Partnership scholarship, and Australian Commonwealth Government’s‘Prioritizing Mental Health Initiative’ grant (2018-19).
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 991083611202621
- Output Type
- Journal article
Metrics
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