Resting-State EEG Correlates of Sustained Attention in Healthy Ageing: Cross-Sectional Findings from the LEISURE Study

Alicia J. Campbell; Toomas Erik Anijärv; Thomas Pace; Ciara Treacy; Jim Lagopoulos; Daniel F. Hermens; Jacob M. Levenstein; Sophie C. Andrews

doi:10.1016/j.neurobiolaging.2024.09.005

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Resting-State EEG Correlates of Sustained Attention in Healthy Ageing: Cross-Sectional Findings from the LEISURE Study

Journal article

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Resting-State EEG Correlates of Sustained Attention in Healthy Ageing: Cross-Sectional Findings from the LEISURE Study

Alicia J. Campbell, Toomas Erik Anijärv, Thomas Pace, Ciara Treacy, Jim Lagopoulos, Daniel F. Hermens, Jacob M. Levenstein and Sophie C. Andrews

Neurobiology of Aging, Vol.144, pp.68-77

2024

DOI: https://doi.org/10.1016/j.neurobiolaging.2024.09.005

PMID: 39288668

Appears in Thompson Institute Research Collection

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Abstract

Age

Aperiodic

Cognition

Electroencephalography

Periodic

Neuroimaging

Thompson Institute Special Collection

Healthy Brain Ageing

UniSC Diversity Area - Life Stages

While structural and biochemical brain changes are well-documented in ageing, functional neuronal network differences, as indicated by electrophysiological markers, are less clear. Moreover, age-related changes in sustained attention and their associated electrophysiological correlates are still poorly understood. To address this, we analysed cross-sectional baseline electroencephalography (EEG) and cognitive data from the Lifestyle Intervention Study for Dementia Risk Reduction (LEISURE). Participants were 96 healthy older adults, aged 50-84. We examined resting-state EEG periodic (individual alpha frequency [IAF], aperiodic-adjusted individual alpha power [aIAP]) and aperiodic (exponent and offset) activity, and their associations with age and sustained attention. Results showed associations between older age and slower IAF, but not aIAP or global aperiodic exponent and offset. Additionally, hierarchical linear regression revealed that after controlling for demographic variables, faster IAF was associated with better Sustained Attention to Response Task performance, and mediation analysis confirmed IAF as a mediator between age and sustained attention performance. These findings indicate that IAF may be an important marker of ageing, and a slower IAF may signal diminished cognitive processing capacity for sustained attention in older adults.

Details

Title: Resting-State EEG Correlates of Sustained Attention in Healthy Ageing: Cross-Sectional Findings from the LEISURE Study
Authors: Alicia J. Campbell (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Toomas Erik Anijärv (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Thomas Pace (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Ciara Treacy (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Jim Lagopoulos (Author) - Thompson Brain and Mind Healthcare (Australia)
Daniel F. Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Jacob M. Levenstein (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Sophie C. Andrews (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Publication details: Neurobiology of Aging, Vol.144, pp.68-77
Publisher: Elsevier Inc.
Date published: 2024
DOI: 10.1016/j.neurobiolaging.2024.09.005
ISSN: 1558-1497
PMID: 39288668
Grant note: This research is supported by an Australian Government Research Training Program (RTP) scholarship. The LEISURE study was funded by a grant from the Wilson Foundation.
Organisation Unit: Healthy Ageing Research Cluster; Thompson Institute
Language: English
Record Identifier: 991064627102621
Output Type: Journal article

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