Responses to methylphenidate in adolescent AD/HD: Evidence from concurrently recorded autonomic (EDA) and central (EEG and ERP) measures

Daniel F Hermens; L M Williams; S Clarke; M Kohn; N Cooper; E Gordon

doi:10.1016/j.ijpsycho.2005.03.006

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Responses to methylphenidate in adolescent AD/HD: Evidence from concurrently recorded autonomic (EDA) and central (EEG and ERP) measures

Journal article

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Responses to methylphenidate in adolescent AD/HD: Evidence from concurrently recorded autonomic (EDA) and central (EEG and ERP) measures

Daniel F Hermens, L M Williams, S Clarke, M Kohn, N Cooper and E Gordon

International Journal of Psychophysiology, Vol.58(1), pp.21-33

2005

DOI: https://doi.org/10.1016/j.ijpsycho.2005.03.006

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Abstract

Attention-deficit/hyperactivity disorder (AD/HD)

electroencephalogram (EEG)

event-related potential (ERPs)

electrodermal activity (EDA)

methylphenidate

This paper aims to examine the effects of methylphenidate (MPH) on integrated baseline and event-related psychophysiological measures in AD/HD. Thirty-four unmedicated AD/HD adolescents (11-17 years; 6 females) were first compared to 34 age- and sex-matched controls, and then re-tested at least 4 weeks after methylphenidate (MPH) medication. In each testing session, EDA was recorded simultaneously with EEG during a resting eyes open condition, and with ERPs during an auditory oddball task. Unmedicated AD/HD subjects were compared to controls and then AD/HD subjects were compared pre- and post-medication. Correlations between the change in EEG theta and the remaining psychophysiological variables were undertaken to provide information about post MPH treatment changes. In the unmedicated state, AD/HD was characterized by abnormally enhanced theta, across fronto-central sites, generally reduced P2 responses, with larger non-specific and oddball-elicited SCRs and poor behavioural performance on the oddball task. Following treatment, AD/HD showed a 'normalization' of theta activity (particularly in the right hemisphere), a reduction in the rate of decrement of EDA and a general increase in P3 amplitude. These findings suggest that methylphenidate is associated with a robust 'normalization' of low frequency EEG activity during the resting brain state, but has less impact on task-related brain activity or phasic changes in autonomic function. This dissociation of resting and task-related activity may prove to be useful in elucidating the effects of stimulant versus new non-stimulant medications in AD/HD. © 2005 Elsevier B.V. All rights reserved.

Details

Title: Responses to methylphenidate in adolescent AD/HD: Evidence from concurrently recorded autonomic (EDA) and central (EEG and ERP) measures
Authors: Daniel F Hermens (Author) - University of Sydney
L M Williams (Author) - University of Sydney
S Clarke (Author) - University of Sydney
M Kohn (Author) - University of Sydney
N Cooper (Author) - Brain Resource Company
E Gordon (Author) - University of Sydney
Publication details: International Journal of Psychophysiology, Vol.58(1), pp.21-33
Publisher: Elsevier BV
Date published: 2005
DOI: 10.1016/j.ijpsycho.2005.03.006
ISSN: 0167-8760
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450325202621
Output Type: Journal article

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