Research Challenges Relating to Immune-Related Patient Outcomes During Blood Transfusion for Spine Surgery

Michelle Roets; David Sturgess; Melinda Dean; Andre Van Zundert; Jonathen H. Waters

doi:10.3390/anesthres1030021

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Research Challenges Relating to Immune-Related Patient Outcomes During Blood Transfusion for Spine Surgery

Journal article

Open access

Peer reviewed

Research Challenges Relating to Immune-Related Patient Outcomes During Blood Transfusion for Spine Surgery

Michelle Roets, David Sturgess, Melinda Dean, Andre Van Zundert and Jonathen H. Waters

Anesthesia Research, Vol.1(3), pp.227-238

2024

DOI: https://doi.org/10.3390/anesthres1030021

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Abstract

blood transfusion

spine surgery

research design

cell salvage

clinical outcomes

Background: In this manuscript, the challenges encountered during research into patient outcomes following transfusion during spine surgery are explored. Method: A narrative review of transfusion research over decades. Results: An estimated 310 million major surgeries occur in the world each year, and 15% of these patients experience serious adverse outcomes (the United States of America, n 5,880,829). Many adverse outcomes are associated with allogeneic blood transfusion (ABT) and are potentially avoided by intraoperative cell salvage (ICS). The incidence of perioperative transfusion in patients who undergo spine surgery varies between 8 and 36%. Conclusions: Knowledge gaps remain due to the complexity of the field of study, confounding factors, the inability to define optimal transfusion triggers, challenges countered in study design, requirements for large sample sizes, and the inability to conduct randomised controlled trials (RCTs). The surgical complexity, subtle patient factors, and differences in policies and procedures across hospitals and countries are difficult to define and add further complexity. Solutions demand well-designed prospective collaborative research projects.

Details

Title: Research Challenges Relating to Immune-Related Patient Outcomes During Blood Transfusion for Spine Surgery
Authors: Michelle Roets (Corresponding Author) - The University of Queensland
David Sturgess - The University of Queensland
Melinda Dean - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
Andre Van Zundert - The University of Queensland
Jonathen H. Waters - University of Pittsburgh
Publication details: Anesthesia Research, Vol.1(3), pp.227-238
Publisher: MDPI AG
Date published: 2024
DOI: 10.3390/anesthres1030021
ISSN: 2813-5806
Copyright note: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Data Availability: No new data were created or analyzed in this study. Data sharing is not applicable to this article.
Organisation Unit: School of Health - Biomedicine
Language: English
Record Identifier: 991093498002621
Output Type: Journal article

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