Repeated treatment with the NMDA antagonist MK-801 disrupts reconsolidation of memory for amphetamine-conditioned place preference

R Sadler; Volker Herzig; W J Schmidt

doi:10.1097/FBP.0b013e3282effb81

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Repeated treatment with the NMDA antagonist MK-801 disrupts reconsolidation of memory for amphetamine-conditioned place preference

Journal article

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Repeated treatment with the NMDA antagonist MK-801 disrupts reconsolidation of memory for amphetamine-conditioned place preference

R Sadler, Volker Herzig and W J Schmidt

Behavioural Pharmacology, Vol.18(7), pp.699-703

2007

DOI: https://doi.org/10.1097/FBP.0b013e3282effb81

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Abstract

amphetamine

conditioned place preference expression

locomotion

memory reconsolidation

MK-801

rats

repeated treatment

Long-lasting drug-associated memories can contribute to relapse; therefore these memories must be inactivated to enable sustainable success in addiction therapy. As drug associations are usually acquired over several conditioning events, we assume that an effective treatment should be repeatedly applied to achieve persistent effects. In this study, we examine whether 10 repeated memory reactivation tests followed by systemic N-methyl-D-aspartate receptor antagonist MK-801 (0.1 mg/kg) administrations can disrupt memory reconsolidation in rats, leading to a reduction of well-established amphetamine-conditioned place preference (CPP). We found that immediate (but not 60-min delayed) administration of MK-801 after the tests reduced amphetamine-CPP expression after at least four treatments. These effects were specific to CPP expression as no MK-801-induced change in locomotion was observed during all tests. We discuss these results as being caused by MK-801 disrupting memory reconsolidation and we propose the applied repeated-treatment regimen as a new therapeutic research strategy to persistently disrupt drug-associated memories.

Details

Title: Repeated treatment with the NMDA antagonist MK-801 disrupts reconsolidation of memory for amphetamine-conditioned place preference
Authors: R Sadler (Author) - University of Tübingen, Germany
Volker Herzig (Author) - University of Tübingen, Germany
W J Schmidt (Author) - University of Tübingen, Germany
Publication details: Behavioural Pharmacology, Vol.18(7), pp.699-703
Publisher: Lippincott Williams & Wilkins
Date published: 2007
DOI: 10.1097/FBP.0b013e3282effb81
ISSN: 0955-8810
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451330902621
Output Type: Journal article

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