Journal article
Repeated-testing of place preference expression for evaluation of anti-craving-drug effects
Amino Acids, Vol.28(3), pp.309-317
2005
Abstract
In addiction research, the conditioned place preference (CPP) paradigm is a widely used animal model of conditioned reward. Usually, CPP development is studied, while only few studies examine CPP expression. In the present study, the suitability of a schedule allowing repeated testing of CPP expression was evaluated. Two groups of rats were either conditioned with cocaine or morphine then the repeated-testing-schedule was applied. This schedule consisted of four repeated applications of a sequence of drug- (i.e. cocaine or morphine), saline- and anti-craving-drug- (i.e. acamprosate, naloxone, their joint administration or saline as internal control) tests. Methodologically, the repeated-testing- schedule produced stable CPP expression in both groups over 12 subsequent tests. In conclusion, it is suggested as a useful method to study effects of anti-craving-drugs on CPP expression, thereby reducing the overall number of experimental animals. The evaluation of the anti-craving-drug effects revealed that neither acamprosate and naloxone given separately nor their combined administration significantly reduced cocaine- or morphine-CPP expression. Thus, we suggest that these anti-craving-drugs are unlikely to be effective for relapse prevention in cocaine- or morphine-addicts.
Details
- Title
- Repeated-testing of place preference expression for evaluation of anti-craving-drug effects
- Authors
- Volker Herzig (Author) - University of Tubingen, GermanyW J Schmidt (Author) - University of Tubingen, Germany
- Publication details
- Amino Acids, Vol.28(3), pp.309-317
- Publisher
- Springer Wien
- Date published
- 2005
- DOI
- 10.1007/s00726-005-0185-x
- ISSN
- 0939-4451
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99451105102621
- Output Type
- Journal article
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