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Ophthalmic Physiologic Optic - 2024 - Lal - Repeatability of retinal and choroidal optical coherence tomography angiography3.50 MB
Published VersionCC BY V4.0, Open Access
Journal article
Repeatability of retinal and choroidal optical coherence tomography angiography indices in healthy children and young adults
Ophthalmic and Physiological Optics, Vol.44(6), pp.1114-1127
2024
PMID: 38923564
Abstract
Purpose
To evaluate the repeatability of retinal and choroidal optical coherence tomography angiography (OCT-A) indices among healthy children and compare it to healthy young adults.
Methods
This prospective study captured 3 mm × 3 mm and 6 mm × 6 mm macular OCT-A scans including superficial and deep retinal layers, choriocapillaris and deep choroid over two visits, 1 week apart at approximately the same time of day, for 22 healthy adults (18–30 years) and 21 children (6–15 years). Magnification and projection-artefact corrected indices extracted using a custom image analysis program and individual biometry were compared between visits using Bland–Altman analysis and intraclass correlation (ICC). Retinal indices included foveal avascular zone metrics, perfusion and vessel density and choroidal indices included choriocapillaris flow deficit metrics and deep choroid perfusion density, in the foveal, parafoveal and perifoveal regions. Repeatability between adults and children was compared with F-test.
Results
Bland–Altman analysis showed that the mean differences between repeated OCT-A indices were not significantly different from zero for either of the zones, layers and scan sizes in the two age groups (p > 0.05) except for foveal vessel density and foveal avascular zone perimeter (p = 0.04 for both) of 6-mm-deep retinal layer scans. The ICC ranged between 0.67 and 0.99. Significantly higher variability between visits (p < 0.05) in the indices was noted among adults than children, especially for choroidal indices of larger scan size.
Conclusion
The retinal and choroidal OCT-A indices in the foveal, parafoveal and perifoveal zones were repeatable in healthy children except for the foveal vessel density and foveal avascular zone perimeter of the 6-mm-deep retinal layer, which exhibited statistically borderline differences between visits. The adult group showed more variability between visits compared to children, especially in the larger scan size for choroidal OCT-A indices.
Details
- Title
- Repeatability of retinal and choroidal optical coherence tomography angiography indices in healthy children and young adults
- Authors
- Barsha Lal (Corresponding Author) - Queensland University of TechnologyDavid Alonso-Caneiro - Queensland University of TechnologyScott A. Read - Queensland University of TechnologyAndrew Carkeet - Queensland University of Technology
- Publication details
- Ophthalmic and Physiological Optics, Vol.44(6), pp.1114-1127
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2024
- DOI
- 10.1111/opo.13357
- ISSN
- 1475-1313; 0275-5408
- PMID
- 38923564
- Copyright note
- © 2024 The Author(s). Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 991050397902621
- Output Type
- Journal article
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