Journal article
Relationships between reduction in symptoms and restoration of function and wellbeing: Outcomes of the Oral Ketamine Trial on Suicidality (OKTOS)
Psychiatry Research, Vol.305, pp.1-7
2021
Abstract
Recovery of functioning is integral to successful treatment outcomes in depressive illness. Optimal antidepressant treatment results in both symptomatic remission and functional recovery. Oral ketamine rapidly reduces suicidality and depression; however, reports of functional and wellbeing outcomes are lacking. This study examines participants’ social and occupational functioning and wellbeing outcomes in the Oral Ketamine Trial on Suicidality (OKTOS). Thirty adults with chronic suicidality participated in the trial over 10 weeks. Functional recovery and wellbeing were assessed using the Social and Occupational Functioning Scale (SOFAS) and World Health Organization Well-Being Index (WHO-5). Suicidality and depressive symptoms were assessed using the Beck Scale for Suicidal ideation (BSS) and Montgomery-Asberg Depression Rating Scale (MADRS). Relationships between the four treatment outcomes were analysed. Forty-three percent of participants achieved healthy function (SOFAS ≥80) and 27% reported healthy wellbeing (WHO-5 >60%) at the four-week post-treatment follow-up. Wellbeing was revealed as the data-derived treatment endpoint for the sample. Effect sizes for functioning and wellbeing outcomes were smaller than for suicidality and depression outcomes. Results suggest that reduction in depressive symptoms and suicidal ideation may be necessary but not sufficient for full resto-ration of function and wellbeing in antisuicidal and antidepressant therapy, including clinical trials.
Details
- Title
- Relationships between reduction in symptoms and restoration of function and wellbeing: Outcomes of the Oral Ketamine Trial on Suicidality (OKTOS)
- Authors
- Denise Beaudequin (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteAdem T Can (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteMonique Jones (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteCian Yang (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJennifer K Scherman (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteMegan Dutton (Author) - University of the Sunshine Coast, Queensland, Thompson InstitutePaul Schwenn (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteCyrana Gallay (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteGrace Forsyth (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteEmma Jensen (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel F Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Psychiatry Research, Vol.305, pp.1-7
- Publisher
- Elsevier Ireland Ltd.
- DOI
- 10.1016/j.psychres.2021.114212
- ISSN
- 1872-7123
- Organisation Unit
- Office of Research; University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99579107602621
- Output Type
- Journal article
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- Psychiatry
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