Regulation of miRNA processing and miRNA mediated gene repression in cancer

Sarah Bajan; Gyorgy Hutvagner

doi:10.2174/2211536602666140110234046

Back

Regulation of miRNA processing and miRNA mediated gene repression in cancer

Journal article

Peer reviewed

Regulation of miRNA processing and miRNA mediated gene repression in cancer

Sarah Bajan and Gyorgy Hutvagner

MicroRNA, Vol.3(1), pp.10-17

2014

DOI: https://doi.org/10.2174/2211536602666140110234046

PMCID: PMC4260356

PMID: 25069508

Files and links (1)

url

https://doi.org/10.2174/2211536602666140110234046View

Published Version

Abstract

Genomics

Neoplasms - genetics

RNA Editing

Humans

Gene Expression Regulation, Neoplastic

MicroRNAs - metabolism

MicroRNAs - genetics

Polymorphism, Single Nucleotide

Neoplasms - pathology

Organ Specificity

Genes, Tumor Suppressor

Oncogenes

The majority of human protein-coding genes are predicted to be targets of miRNA-mediated post-transcriptional regulation. The widespread influence of miRNAs is illustrated by their essential roles in all biological processes. Regulated miRNA expression is essential for maintaining cellular differentiation; therefore alterations in miRNA expression patterns are associated with several diseases, including various cancers. High-throughput sequencing technologies revealed low level expressing miRNA isoforms, termed isomiRs. IsomiRs may differ in sequence, length, target preference and expression patterns from their parental miRNA and can arise from differences in miRNA biosynthesis, RNA editing, or SNPs inherent to the miRNA gene. The association between isomiR expression and disease progression is largely unknown. Misregulated miRNA expression is thought to contribute to the formation and/or progression of cancer. However, due to the diversity of targeted transcripts, miRNAs can function as both tumor-suppressor genes and oncogenes as defined by cellular context. Despite this, miRNA profiling studies concluded that the differential expression of particular miRNAs in diseased tissue could aid the diagnosis and treatment of some cancers.

Details

Title: Regulation of miRNA processing and miRNA mediated gene repression in cancer
Authors: Sarah Bajan (Author) - University of Technology Sydney
Gyorgy Hutvagner (Author) - University of Technology Sydney
Publication details: MicroRNA, Vol.3(1), pp.10-17
Publisher: Bentham Science Publishers Ltd.
DOI: 10.2174/2211536602666140110234046
ISSN: 2211-5374
PMID: 25069508; PMC4260356
Organisation Unit: School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Biomedicine
Language: English
Record Identifier: 99472505902621
Output Type: Journal article

Metrics

29 Record Views