Regulated nucleocytoplasmic transport in spermatogenesis: A driver of cellular differentiation?

C Hogarth; Catherine Itman; D A Jans; K L Loveland

doi:10.1002/bies.20289

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Regulated nucleocytoplasmic transport in spermatogenesis: A driver of cellular differentiation?

Journal article

Peer reviewed

Regulated nucleocytoplasmic transport in spermatogenesis: A driver of cellular differentiation?

C Hogarth, Catherine Itman, D A Jans and K L Loveland

BioEssays, Vol.27(10), pp.1011-1025

2005

DOI: https://doi.org/10.1002/bies.20289

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Abstract

cell cycle protein

CRE modulator protein

cyclic AMP

cycline

karyopherin

karyopherin alpha

karyopherin beta

nuclear protein

nucleoporin

octamer transcription factor 4

regulator protein

Smad protein

sonic hedgehog protein

transcription factor

This review explores the hypothesis that regulation of nucleocytoplasmic shuttling is a means of driving differentiation, using spermatogenesis as a model. The transition from undifferentiated spermatogonial stem cell to terminally differentiated spermatozoon is, at its most basic, a change in the repertoire of expressed genes. To effect this, the complement of nuclear proteins, such as transcription factors and chromatin remodelling components must change. Current knowledge of the nuclear proteins and nucleocytoplasmic transport machinery relevant to spermatogenesis is consolidated in this review, and their functional linkages are highlighted not only as a means of regulating nuclear protein composition, but also as a key mechanism regulating gene transcription and hence cell fate. Through this, we hypothesize that male germ cell differentiation is mediated through regulation of nuclear transport machinery components, and thereby of the access of critical factors to the nucleus. The importance of nucleocytoplasmic trafficking to male germ cell differentiation is discussed, using the sex-determining factors Sry and SOX9, cell cycle regulators, CREM and cofactors and the Smads as specific examples, together with the roles in gametogenesis for particular nuclear transport factors in Caenorhabditis elegans and Drosophila. © 2005 Wiley Periodicals, Inc.

Details

Title: Regulated nucleocytoplasmic transport in spermatogenesis: A driver of cellular differentiation?
Authors: C Hogarth (Author) - Monash University
Catherine Itman (Author) - Monash University
D A Jans (Author) - Monash University
K L Loveland (Author) - Monash University
Publication details: BioEssays, Vol.27(10), pp.1011-1025
Publisher: John Wiley & Sons Ltd.
Date published: 2005
DOI: 10.1002/bies.20289
ISSN: 0265-9247
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449170002621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Biology

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