Files and links (1)
Ophthalmic Physiologic Optic - 2025 - Iqbal - Regional variations in corneal oedema during open‐eye fenestrated scleral2.82 MB
Published VersionCC BY V4.0, Open Access
Journal article
Regional variations in corneal oedema during open-eye fenestrated scleral lens wear
Ophthalmic and Physiological Optics, Vol.45(3), pp.618-626
2025
PMID: 40078117
Abstract
Purpose
To compare the magnitude of central, mid-peripheral and peripheral stromal corneal oedema induced during short-term fenestrated and non-fenestrated scleral lens wear.
Methods
Nine healthy participants wore a non-fenestrated and a fenestrated (0.3-mm diameter limbal fenestration) scleral lens (KATT™, Capricornia Contact Lenses), hexafocon B material (Dk 141 × 10−11 cm3 O2(cm)/[(s) (cm2) (mmHg)]) in one eye under open-eye conditions for 90 min on two separate days. Scleral lens thickness, fluid reservoir thickness and stromal corneal oedema were measured using high-resolution optical coherence tomography. Stromal oedema was quantified across the central (0–2.5 mm from the corneal apex), mid-peripheral (−3.0 to −1.0 mm from the scleral spur) and peripheral (−1.0 to 0 mm from the scleral spur) cornea with the lens in situ. The magnitude of oedema was corrected based on variations in fluid reservoir thickness between the lens conditions.
Results
There was a significant effect of lens type (p = 0.04) on stromal oedema, with less oedema observed with the fenestrated (0.36 ± 0.45%) compared to the non-fenestrated lenses (1.24 ± 0.27%), averaged across all corneal locations. A significant lens type by corneal location interaction was also observed (p = 0.05), with less oedema observed in the peripheral region for the fenestrated (−0.15 ± 0.98%) compared to the non-fenestrated lenses (1.81 ± 0.57%) (p = 0.048). A fenestration location by corneal location interaction was also observed (p = 0.02), indicating a greater reduction in oedema closer to the fenestration.
Conclusions
Central and mid-peripheral stromal oedema was similar during fenestrated and non-fenestrated lens wear; however, fenestrated lenses displayed significantly less oedema in the peripheral cornea. This is most likely due to increased oxygen delivery in proximity to the fenestration.
Details
- Title
- Regional variations in corneal oedema during open-eye fenestrated scleral lens wear
- Authors
- Asif Iqbal (Corresponding Author) - Queensland University of TechnologyDamien Fisher - Queensland University of TechnologyDavid Alonso-Caneiro - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringMichael J Collins - Queensland University of TechnologyStephen J Vincent - Queensland University of Technology
- Publication details
- Ophthalmic and Physiological Optics, Vol.45(3), pp.618-626
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2025
- DOI
- 10.1111/opo.13489
- ISSN
- 1475-1313; 0275-5408
- PMID
- 40078117
- Copyright note
- © 2025 The Author(s). Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Grant note
- QUT Postgraduate Research Award PhD scholarship; Dorothy Carlborg Research Award from the Cornea and Contact Lens Society of Australia
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 991112031902621
- Output Type
- Journal article
Metrics
8 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Ophthalmology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites