Reducing false positive diagnoses in mild cognitive impairment: the importance of comprehensive neuropsychological assessment

S Z Klekociuk; J J Summers; J C Vickers; Mathew J Summers

doi:10.1111/ene.12488

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Reducing false positive diagnoses in mild cognitive impairment: the importance of comprehensive neuropsychological assessment

Journal article

Peer reviewed

Reducing false positive diagnoses in mild cognitive impairment: the importance of comprehensive neuropsychological assessment

S Z Klekociuk, J J Summers, J C Vickers and Mathew J Summers

European Journal of Neurology, Vol.21(10), pp.1330-1336

2014

DOI: https://doi.org/10.1111/ene.12488

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Abstract

Clinical Sciences

Neurosciences

dementia

diagnosis

mild cognitive impairment

neuropsychology

recovery

stability

Background and purpose: Longitudinal studies of mild cognitive impairment (MCI) report that a sizeable proportion of MCI cases revert to normal levels of functioning over time. The rate of recovery from MCI indicates that existing MCI diagnostic criteria result in an unacceptably high rate of false positive diagnoses and lack adequate sensitivity and specificity. Methods: The aim of the present study was to identify a set of neuropsychological measures able to differentiate between true positive cases of MCI from those who were unimpaired at 11 months' follow-up. Results: A discriminant function analysis identified that a combination of measures of complex sustained attention, semantic memory, working memory, episodic memory and selective attention correctly classified outcome in more than 80% of cases. The rate of false positive diagnoses (5.93%) was considerably lower than is evident in previously published MCI studies. Conclusions: The results of the present study indicate that the rate of false positive MCI diagnoses can be significantly reduced through the use of sensitive and specific neuropsychological measures of memory and non-memory functions.

Details

Title: Reducing false positive diagnoses in mild cognitive impairment: the importance of comprehensive neuropsychological assessment
Authors: S Z Klekociuk (Author) - University of Tasmania
J J Summers (Author) - University of Tasmania
J C Vickers (Author) - University of Tasmania
Mathew J Summers (Author) - University of Tasmania
Publication details: European Journal of Neurology, Vol.21(10), pp.1330-1336
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2014
DOI: 10.1111/ene.12488
ISSN: 1351-5101
Organisation Unit: School of Health; School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99448643402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences

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