Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections

J Debattista; Peter Timms; Janet M Allan; John A Allan

doi:10.1016/S0165-2478(02)00036-6

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Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections

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Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections

J Debattista, Peter Timms, Janet M Allan and John A Allan

Immunology Letters, Vol.81(3), pp.205-210

2002

DOI: https://doi.org/10.1016/S0165-2478(02)00036-6

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Abstract

chlamydia trachomatis

immunopathogenesis

cytokines

gamma interferon

interleukin-10

heat shock protein

pelvic inflammatory disease

Peripheral lymphocytes in uninfected fertile controls, women with various histories of Chlamydia trachomatis infection, pelvic inflammatory disease (PID) and infertility not due to C. trachomatis infection (endometriosis) were cultured overnight with PHA mitogen and the 60 kDa chlamydial heat shock protein. Plasma samples were then assayed for levels of gamma-interferon and IL-10 using a commercial ELISA system. Women with PID and those with a history of multiple C. trachomatis infections showed reduced gamma-interferon production in response to cHSP60, not seen in women infected only once and those with infertility due to other causes (endometriosis). Secretion of IL-10 in response to cHSP60 did not vary significantly across the various patient groups, though all patients showed elevated levels of total IL-10 compared with uninfected controls. © 2002 Elsevier Science B.V. All rights reserved.

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Title: Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections
Authors: J Debattista (Author) - Queensland University of Technology
Peter Timms (Author) - Queensland University of Technology
Janet M Allan (Author) - Wesley Hospital
John A Allan (Author) - Wesley Hospital
Publication details: Immunology Letters, Vol.81(3), pp.205-210
Publisher: Elsevier BV
DOI: 10.1016/S0165-2478(02)00036-6
ISSN: 0165-2478
Organisation Unit: Centre for Bioinnovation; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450147402621
Output Type: Journal article

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