Reduced cerebral pressure-flow responses are associated with electrophysiological markers of attention in healthy older adults

Kayla Stefanidis; Ben Isbel; Timo Klein; Jim Lagopoulos; Christopher Askew; Mathew Summers

doi:10.1016/j.jocn.2020.09.034

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Reduced cerebral pressure-flow responses are associated with electrophysiological markers of attention in healthy older adults

Journal article

Peer reviewed

Reduced cerebral pressure-flow responses are associated with electrophysiological markers of attention in healthy older adults

Kayla Stefanidis, Ben Isbel, Timo Klein, Jim Lagopoulos, Christopher Askew and Mathew Summers

Journal of Clinical Neuroscience, Vol.81, pp.167-172

2020

DOI: https://doi.org/10.1016/j.jocn.2020.09.034

PMID: 33222909

Appears in Thompson Institute Research Collection

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https://doi.org/10.1016/j.jocn.2020.09.034View

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Abstract

aging

age-related cognitive decline

Transcranial Doppler

middle cerebral artery blood flow velocity (MCAv)

event-related potentials

auditory oddball

Healthy Brain Ageing

Thompson Institute Special Collection

UniSC Diversity Area - Life Stages

The aim of this study was to determine the effect of age on the relationship between cerebrovascular function and the neural bases of sustained attention. Twenty-seven healthy young adults (aged 18–30 years) and 24 older adults (60–75 years) underwent assessments of cerebrovascular function and sustained attention. Blood flow velocity of the middle cerebral artery was assessed via Transcranial Doppler Ultrasound, during seated rest, in response to hypocapnic breathing (cerebrovascular reactivity) and during a repeated sit-to-stand procedure (pressure-flow response). Attentional processing was assessed using the N2 and P3 components of the event-related potential during a two-tone auditory oddball task. Poorer pressure-flow responses were significantly associated with reductions in N2 and P3 amplitude in the old group (b = −0.50, p = .029 and b = −0.46, p = .045), but not the young group. These results suggest that alterations in the brain’s capacity to combat reductions in perfusion pressure are associated with age-related differences in attentional processing, supporting the hypothesis that cerebrovascular hemodynamic disturbances play a role in age-related cognitive decline.

Details

Title: Reduced cerebral pressure-flow responses are associated with electrophysiological markers of attention in healthy older adults
Authors: Kayla Stefanidis (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Ben Isbel (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Timo Klein (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Christopher Askew (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
Mathew Summers (Author) - University of the Sunshine Coast, Queensland, School of Social Sciences - Legacy
Publication details: Journal of Clinical Neuroscience, Vol.81, pp.167-172
Publisher: Elsevier Ltd.
Date published: 2020
DOI: 10.1016/j.jocn.2020.09.034
ISSN: 1532-2653
PMID: 33222909
Organisation Unit: Road Safety Research Collaboration; School of Health; School of Social Sciences - Legacy; School of Health and Sport Sciences - Legacy; Thompson Institute; Cancer Research Cluster; School of Health - Psychology; School of Health - Sports & Exercise Science; School of Law and Society; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99483708202621
Output Type: Journal article

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