Journal article
Reduced cerebral pressure-flow responses are associated with electrophysiological markers of attention in healthy older adults
Journal of Clinical Neuroscience, Vol.81, pp.167-172
2020
Appears in Thompson Institute Research Collection
Abstract
The aim of this study was to determine the effect of age on the relationship between cerebrovascular function and the neural bases of sustained attention. Twenty-seven healthy young adults (aged 18–30 years) and 24 older adults (60–75 years) underwent assessments of cerebrovascular function and sustained attention. Blood flow velocity of the middle cerebral artery was assessed via Transcranial Doppler Ultrasound, during seated rest, in response to hypocapnic breathing (cerebrovascular reactivity) and during a repeated sit-to-stand procedure (pressure-flow response). Attentional processing was assessed using the N2 and P3 components of the event-related potential during a two-tone auditory oddball task. Poorer pressure-flow responses were significantly associated with reductions in N2 and P3 amplitude in the old group (b = −0.50, p = .029 and b = −0.46, p = .045), but not the young group. These results suggest that alterations in the brain’s capacity to combat reductions in perfusion pressure are associated with age-related differences in attentional processing, supporting the hypothesis that cerebrovascular hemodynamic disturbances play a role in age-related cognitive decline.
Details
- Title
- Reduced cerebral pressure-flow responses are associated with electrophysiological markers of attention in healthy older adults
- Authors
- Kayla Stefanidis (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteBen Isbel (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteTimo Klein (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteChristopher Askew (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyMathew Summers (Author) - University of the Sunshine Coast, Queensland, School of Social Sciences - Legacy
- Publication details
- Journal of Clinical Neuroscience, Vol.81, pp.167-172
- Publisher
- Elsevier Ltd.
- Date published
- 2020
- DOI
- 10.1016/j.jocn.2020.09.034
- ISSN
- 1532-2653
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; School of Health - Psychology; School of Health; School of Social Sciences - Legacy; Thompson Institute; School of Law and Society; School of Health - Sports & Exercise Science; Road Safety Research Collaboration; Cancer Research Cluster
- Language
- English
- Record Identifier
- 99483708202621
- Output Type
- Journal article
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- Web Of Science research areas
- Clinical Neurology
- Neurosciences
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