Recommendations of the ISBT Working Party on Granulocyte Immunobiology for leucocyte antibody screening in the investigation and prevention of antibody-mediated transfusion-related acute lung injury
Vox Sanguinis, Vol.96(3), pp.266-269
2009
Background Transfusion-related acute lung injury (TRALI) is currently one of the most common causes of transfusion-related major morbidity and death. Among the many TRALI mediators, leucocyte antibodies have been identified as important triggers of severe TRALI. Study Design and Methods These recommendations were compiled by experts of the ISBT Working Party on Granulocyte Immunobiology, based on the results obtained in eight international granulocyte immunology workshops, their personal experiences and on published study results. Results Leucocyte antibody screening has to include the detection of human leucocyte antigen (HLA) class I, class II and human neutrophil alloantigen antibodies using established and validated techniques. HLA class I antibody detection should be restricted to antibodies clinically relevant for TRALI. To avoid unnecessary workload, TRALI diagnosis should be assessed by consultation with the reporting clinician and thorough exclusion of transfusion-associated circulatory overload/cardiac insufficiency. In patients diagnosed with TRALI having donors with detectable leucocyte antibodies, evidence of leucocyte incompatibility should be provided by either cross-matching or typing of patient for cognate antigen. Conclusion Leucocyte antibody screening for the immunological clarification of TRALI cases as well as for identification of potentially alloimmunized blood donors is feasible and can be performed in a reasonable and quality assured manner. This practice can contribute to the prevention of antibody-mediated TRALI.
- Recommendations of the ISBT Working Party on Granulocyte Immunobiology for leucocyte antibody screening in the investigation and prevention of antibody-mediated transfusion-related acute lung injury
- P Bierling (Author) - Hopital Henri Mondor, FranceJ Bux (Author) - Blood Service West of the German Red Cross, GermanyB Curtis (Author) - Platelet and Neutrophil Immunology Laboratory, United StatesB Flesch (Author) - University of Schleswig-Holstein, GermanyYoke Lin Fung (Author) - Australian Red Cross Blood ServiceG Lucas (Author) - National Blood Service, United KingdomM Macek (Author) - Blood Transfusion Center of Slovenia, SloveniaE Muniz-Dias (Author) - Hospital Vall d-Hebron, SpainI Porcelijn (Author) - Sanquin Diagnostic Services, NetherlandsA Reil (Author) - Blood Service West of the German Red Cross, GermanyU Sachs (Author) - Justus-Liebig University, GermanyR Schuller (Author) - Neutrophil Serology Laboratory, United StatesN Tsuno (Author) - University of Tokyo, JapanM Uhrynowska (Author) - Institute of Haematology and Blood Transfusion, PolandS Urbaniak (Author) - Scottish National Blood Transfusion Service, United KingdomN Valentin (Author) - Institute of Biology, FranceA Wikman (Author) - Karolinksa University Hospital, SwedenB Zupanska (Author) - Institute of Haematology and Blood Transfusion, Poland
- Vox Sanguinis, Vol.96(3), pp.266-269
- Wiley-Blackwell Publishing Ltd.
- 2009
- 10.1111/j.1423-0410.2008.01144.x
- 0042-9007
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- English
- 99448844402621
- Journal article
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615
research.portal.fulldisplay.incitesHighlights.intro
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- Hematology
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