Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

Yoke Lin Fung; M Kim; A Tabuchi; R Aslam; E R Speck; L Chow; W M Kuebler; J Freedman; J W Semple

doi:10.1182/blood-2010-05-284570

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Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

Journal article

Peer reviewed

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

Yoke Lin Fung, M Kim, A Tabuchi, R Aslam, E R Speck, L Chow, W M Kuebler, J Freedman and J W Semple

Blood, Vol.116(16), pp.3073-3079

2010

DOI: https://doi.org/10.1182/blood-2010-05-284570

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Abstract

TRALI

transfusion-related fatalities

Transfusion-related acute lung injury (TRALI) is a serious complication of transfusion and has been ranked as one of the leading causes of transfusion-related fatalities. Nonetheless, many details of the immunopathogenesis of TRALI, particularly with respect to recipient factors are unknown. We used a murine model of antibody-mediated TRALI in an attempt to understand the role that recipient lymphocytes might play in TRALI reactions. Intravenous injection of an IgG2a antimurine major histocompatibility complex class I antibody (34-1-2s) into BALB/c mice induced moderate hypothermia and pulmonary granulocyte accumulation but no pulmonary edema nor mortality. In contrast, 34-1-2s injections into mice with severe combined immunodeficiency caused severe hypothermia, severe pulmonary edema, and approximately 40% mortality indicating a critical role for T and B lymphocytes in suppressing TRALI reactions. Adoptive transfer of purified CD8 + T lymphocytes or CD4 + T cells but not CD19 + B cells into the severe combined immunodeficiency mice alleviated the antibody-induced hypothermia, lung damage, and mortality, suggesting that T lymphocytes were responsible for the protective effect. Taken together, these results suggest that recipient T lymphocytes play a significant role in suppressing antibody-mediated TRALI reactions. They identify a potentially new recipient mechanism that controls the severity of TRALI reactions. © 2010 by The American Society of Hematology.

Details

Title: Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury
Authors: Yoke Lin Fung (Author) - University of Queensland
M Kim (Author) - Li Ka Shing Knowledge Institute of St Michael's Hospital, Canada
A Tabuchi (Author) - Li Ka Shing Knowledge Institute of St Michael's Hospital, Canada
R Aslam (Author) - Canadian Blood Service, Canada
E R Speck (Author) - Canadian Blood Service, Canada
L Chow (Author) - Canadian Blood Service, Canada
W M Kuebler (Author) - Li Ka Shing Knowledge Institute of St Michael's Hospital, Canada
J Freedman (Author) - Li Ka Shing Knowledge Institute of St Michael's Hospital, Canada
J W Semple (Author) - Li Ka Shing Knowledge Institute of St Michael's Hospital, Canada
Publication details: Blood, Vol.116(16), pp.3073-3079
Publisher: American Society of Hematology
Date published: 2010
DOI: 10.1182/blood-2010-05-284570
ISSN: 0006-4971
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449923802621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Hematology

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