Journal article
Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery
Biomaterials Science, Vol.11(16), pp.5390-5409
2023
PMID: 37387317
Abstract
Microneedles (MNs) have recently been found to have applications in drug, vitamin, protein and vaccine delivery. Polymeric MN arrays continue to attract increasing attention due to their capability to bypass the skin's stratum corneum (SC) barrier with minimal invasiveness. These carriers can achieve the targeted intradermal delivery of drugs and vaccines and improve their transdermal delivery level. As a nontoxic FDA-approved copolymer, polylactic glycolic acid (PLGA) has good biocompatibility and biodegradability. Currently, PLGA-based MNs have a noticeable tendency to be utilized as a delivery system. This study focuses on the most recent advances in PLGA-based MNs. Both PLGA nanoparticle-based MNs and PLGA matrix-based MNs, created for the delivery of vaccines, drugs, proteins and other therapeutic agents, are discussed. The paper also discusses the various types of MNs and their potential applications. Finally, the prospects and challenges of PLGA-based MNs are reviewed.
Details
- Title
- Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery
- Authors
- Atefeh Malek-Khatabi - Tehran University of Medical SciencesMalihe Sadat Razavi - Tehran University of Medical SciencesAlyeh Abdollahi - Tehran University of Medical SciencesMilad Rahimzadeghan - Shahid Beheshti University of Medical SciencesFatemeh Moammeri - Mashhad University of Medical SciencesMojgan Sheikhi - Tehran University of Medical SciencesMohamadreza Tavakoli - Tehran University of Medical SciencesMazda Rad-Malekshahi (Corresponding Author) - Tehran University of Medical SciencesZahra Faraji Rad (Corresponding Author) - University of Southern Queensland
- Publication details
- Biomaterials Science, Vol.11(16), pp.5390-5409
- Publisher
- Royal Society of Chemistry
- Date published
- 2023
- DOI
- 10.1039/d3bm00795b
- ISSN
- 2047-4849
- PMID
- 37387317
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 991140405002621
- Output Type
- Journal article
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