Re-evaluating the residual risk of transfusion-transmitted Ross River virus infection

C R Seed; V C Hoad; Helen M Faddy; P Kiely; A J Keller; J Pink

doi:10.1111/vox.12372

Back

Re-evaluating the residual risk of transfusion-transmitted Ross River virus infection

Journal article

Peer reviewed

Re-evaluating the residual risk of transfusion-transmitted Ross River virus infection

C R Seed, V C Hoad, Helen M Faddy, P Kiely, A J Keller and J Pink

Vox Sanguinis, Vol.110(4), pp.317-323

2016

DOI: https://doi.org/10.1111/vox.12372

Files and links (1)

url

https://doi.org/10.1111/vox.12372View

Published Version

Abstract

Clinical Sciences

Medical Physiology

blood safety

residual risk estimation

Ross River virus

transfusion-transmissible infection

Background and objectives: Ross River virus (RRV) is an enveloped, RNA alphavirus in the same antigenic group as chikungunya virus. Australia records an annual average of 5000 laboratory-confirmed RRV infections. While RRV is currently geographically restricted to the Western Pacific, the capacity of arboviruses for rapid expansion is well established. The first case of RRV transfusion-transmission was recently described prompting a comprehensive risk assessment. Materials and methods: To estimate the RRV residual risk, we applied laboratory-confirmed RRV notifications to two published models. This modelling generated point estimates for the risk of viraemia in the donor population, the risk of collecting a viraemic donation and the predicted number of infected components. Results: The EUFRAT model estimated the risk of infection in donors as one in 95 039 (one in 311 328 to one in 32 399) to one in 14 943 (one in 48 593 to one in 5094). The point estimate for collecting a RRV viraemic donation varied from one in 166 486 (one in 659 078 to one in 49 158) (annualized national risk) to one in 26 117 (one in 103 628 to one in 7729) (area of high transmission). The modelling predicted 8-11 RRV-infected labile blood components issued in Australia during a 1-year period. Conclusion: Considering the uncertainty in the modelled estimates, the unknown rate of RRV donor viraemia and the low severity of any recipient RRV infection, additional risk management for RRV in Australia will initially be restricted to strengthening the messaging to donors regarding prompt reporting of any postdonation illnesses.

Details

Title: Re-evaluating the residual risk of transfusion-transmitted Ross River virus infection
Authors: C R Seed (Corresponding Author) - Australian Red Cross Blood Service
V C Hoad (Author) - Australian Red Cross Blood Service
Helen M Faddy (Author) - Australian Red Cross Blood Service
P Kiely (Author) - Australian Red Cross Blood Service
A J Keller (Author) - Australian Red Cross Blood Service
J Pink (Author) - Australian Red Cross Blood Service
Publication details: Vox Sanguinis, Vol.110(4), pp.317-323
Publisher: Wiley-Blackwell Publishing Ltd.
DOI: 10.1111/vox.12372
ISSN: 0042-9007; 1423-0410
Organisation Unit: School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Biomedicine
Language: English
Record Identifier: 99450829102621
Output Type: Journal article

Metrics

27 Record Views

8 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Web Of Science research areas: Hematology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites