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Published VersionCC BY V4.0, Open Access
Journal article
Randomised, controlled, feasibility trial comparing vasopressor infusion administered via peripheral cannula versus central venous catheter for critically ill adults: A study protocol
PLoS One, Vol.19(5), pp.1-12
2024
Abstract
Background
When clinicians need to administer a vasopressor infusion, they are faced with the choice of administration via either peripheral intravenous catheter (PIVC) or central venous catheter (CVC). Vasopressor infusions have traditionally been administered via central venous catheters (CVC) rather than Peripheral Intra Venous Catheters (PIVC), primarily due to concerns of extravasation and resultant tissue injury. This practice is not guided by contemporary randomised controlled trial (RCT) evidence. Observational data suggests safety of vasopressor infusion via PIVC. To address this evidence gap, we have designed the “Vasopressors Infused via Peripheral or Central Access” (VIPCA) RCT.
Methods
The VIPCA trial is a single-centre, feasibility, parallel-group RCT. Eligible critically ill patients requiring a vasopressor infusion will be identified by emergency department (ED) or intensive care unit (ICU) staff and randomised to receive vasopressor infusion via either PIVC or CVC. Primary outcome is feasibility, a composite of recruitment rate, proportion of eligible patients randomised, protocol fidelity, retention and missing data. Primary clinical outcome is days alive and out of hospital up to day-30. Secondary outcomes will include safety and other clinical outcomes, and process and cost measures. Specific aspects of safety related to vasopressor infusions such as extravasation, leakage, device failure, tissue injury and infection will be assessed.
Discussion
VIPCA is a feasibility RCT whose outcomes will inform the feasibility and design of a multicentre Phase-3 trial comparing routes of vasopressor delivery. The exploratory economic analysis will provide input data for the full health economic analysis which will accompany any future Phase-3 RCT.
Details
- Title
- Randomised, controlled, feasibility trial comparing vasopressor infusion administered via peripheral cannula versus central venous catheter for critically ill adults: A study protocol
- Authors
- Stacey Watts - Caboolture Hospital (Australia)Yogesh Apte - The University of QueenslandThomas Holland - Caboolture Hospital (Australia)April Hatt - Caboolture Hospital (Australia)Alison Craswell - University of the Sunshine Coast, Queensland, School of Health - NursingFrances Lin - University of the Sunshine Coast, Queensland, School of Health - NursingAlexis Tabah - Redcliffe HospitalRobert Ware - Griffith UniversityJoshua Byrnes - Griffith UniversityChristopher Anstey - Griffith UniversityGerben Keijzers - Bond UniversityMahesh Ramanan - Caboolture Hospital (Australia)
- Publication details
- PLoS One, Vol.19(5), pp.1-12
- Publisher
- Public Library of Science
- Date published
- 2024
- DOI
- 10.1371/journal.pone.0295347
- ISSN
- 1932-6203
- Copyright note
- © 2024 Watts et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Data Availability
- No datasets were generated or analysed during the current study. All relevant data from this study will be made available upon study completion.
- Organisation Unit
- Healthy Ageing Research Cluster; School of Health - Nursing
- Language
- English
- Record Identifier
- 991024392702621
- Output Type
- Journal article
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