Journal article
RNA silencing in plants: yesterday, today, and tomorrow
Plant Physiology, Vol.147(2), pp.456-468
2008
PMCID: PMC2409047
PMID: 18524877
Abstract
RNA silencing has become a major focus of molecular biology and biomedical research around the world. This is highlighted by a simple PubMed search for “RNA silencing,” which retrieves almost 9,000 articles. Interest in gene silencing-related mechanisms stemmed from the early 1990s, when this phenomenon was first noted as a surprise observation by plant scientists during the course of plant transformation experiments, in which the introduction of a transgene into the genome led to the silencing of both the transgene and homologous endogenes. From these initial studies, plant biologists have continued to generate a wealth of information into not only gene silencing mechanisms but also the complexity of these biological pathways as well as revealing their multilevel interactions with one another. The plant biology community has also made significant advancements in exploiting RNA silencing as a powerful tool for gene function studies and crop improvements.
In this article, we (1) review the rich history of gene silencing research and the knowledge it has generated into our understanding of this fundamental mechanism of gene regulation in plants; (2) describe examples of the current applications of RNA silencing in crop plants; and (3) discuss improvements in RNA silencing technology and its potential application in plant science.
Details
- Title
- RNA silencing in plants: yesterday, today, and tomorrow
- Authors
- Andrew Eamens (Author) - Commonwealth Scientific and Industrial Research OrganisationMing-Bo Wang (Author) - Commonwealth Scientific and Industrial Research OrganisationNeil A. Smith (Author) - Commonwealth Scientific and Industrial Research OrganisationPeter M. Waterhouse (Author) - Commonwealth Scientific and Industrial Research Organisation
- Publication details
- Plant Physiology, Vol.147(2), pp.456-468
- Publisher
- American Society of Plant Biologists
- DOI
- 10.1104/pp.108.117275
- ISSN
- 1532-2548
- PMID
- 18524877; PMC2409047
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health - Biomedicine
- Language
- English
- Record Identifier
- 99656589402621
- Output Type
- Journal article
Metrics
64 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Plant Sciences
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Source: InCites