Quinolines as chemotherapeutic agents for leishmaniasis

K A Reynolds; W A Loughlin; David James Young

doi:10.2174/1389557511313050010

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Quinolines as chemotherapeutic agents for leishmaniasis

Journal article

Peer reviewed

Quinolines as chemotherapeutic agents for leishmaniasis

K A Reynolds, W A Loughlin and David James Young

Mini-Reviews in Medicinal Chemistry, Vol.13(5), pp.730-743

2013

DOI: https://doi.org/10.2174/1389557511313050010

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Abstract

leishmaniasis

quinolines

affordable chemotherapies

The development of leishmanicidal quinolines and their in vitro (promastigote and amastigote) and, where applicable, in vivo activities are reviewed. This survey provides a direct comparison of bioactivity across different species (e.g. L. donovani, L. amazonensis, L. chagasi, L infantum), and in different animal models (e.g. L. donovani Balb/c mice and L. donovani infected hamsters). The progress of selected quinolines through pre-clinical development and phase I/II trials, and the lead quinoline drugs sitamaquinine and Imiquimod, are discussed in conjunction with delivery systems and combination therapies. © 2013 Bentham Science Publishers.

Details

Title: Quinolines as chemotherapeutic agents for leishmaniasis
Authors: K A Reynolds (Author) - Universiti Brunei Darussalam, Brunei
W A Loughlin (Author) - Universiti Brunei Darussalam, Brunei
David James Young (Author) - Universiti Brunei Darussalam, Brunei
Publication details: Mini-Reviews in Medicinal Chemistry, Vol.13(5), pp.730-743
Publisher: Bentham Science Publishers Ltd.
Date published: 2013
DOI: 10.2174/1389557511313050010
ISSN: 1389-5575
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449394502621
Output Type: Journal article

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