Quantitative morphologic evaluation of white matter in survivors of childhood medulloblastoma

Zack Y Shan; J Z Liu; J O Glass; A Gajjar; C S Li; W E Reddick

doi:10.1016/j.mri.2006.04.015

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Quantitative morphologic evaluation of white matter in survivors of childhood medulloblastoma

Journal article

Peer reviewed

Quantitative morphologic evaluation of white matter in survivors of childhood medulloblastoma

Zack Y Shan, J Z Liu, J O Glass, A Gajjar, C S Li and W E Reddick

Magnetic Resonance Imaging, Vol.24(8), pp.1015-1022

2006

DOI: https://doi.org/10.1016/j.mri.2006.04.015

PMID: 16997071

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Abstract

Fractal

Neurotoxicity

Pediatric brain tumor survivors

White matter

article

boundary layer

brain size

density

female

fractal analysis

geometry

human

major clinical study

male

medulloblastoma

mental deterioration

monitor

morphology

multipl

In survivors of pediatric brain tumors, cranial radiation therapy can cause a debilitating cognitive decline associated with decreased volume in normal-appearing white matter (NAWM). We applied fractal geometry to quantify white matter (WM) integrity in the brain of medulloblastoma survivors. Fractal features of WM were evaluated by indices of fractal dimensions (FDs) of WM intensity and boundary on T1-weighted magnetic resonance images. The FD index of WM intensity was calculated by using a fractional Brownian motion model, and the FD index of WM boundary was calculated by using a box-counting method. Fractal features of WM on 116 magnetic resonance images of 58 patients with medulloblastoma were investigated at the start of therapy (Start TX) and approximately 2 years later (After TX). Patients were assigned to one of two groups based on change in NAWM volumes. Fractal features in patients with decreased NAWM volume were significantly greater After TX, whereas those in patients with increased NAWM volumes were not. Multiple linear regression analysis showed that fractal features were strongly correlated with NAWM volumes After TX in patients with decreased NAWM volume. These results demonstrated significant deficit in NAWM integrity and WM density changes in children treated for medulloblastoma. Multiple regression analysis illustrated that deficits in NAWM integrity in these children may partly explain the decrease in NAWM volume. We conclude that fractal geometry can be used to monitor the morphologic effects of neurotoxicity in brain tumor survivors.

Details

Title: Quantitative morphologic evaluation of white matter in survivors of childhood medulloblastoma
Authors: Zack Y Shan (Author) - St. Jude Children's Research Hospital
J Z Liu (Author) - Cleveland Clinic
J O Glass (Author) - St. Jude Children's Research Hospital
A Gajjar (Author) - St. Jude Children's Research Hospital
C S Li (Author) - St. Jude Children's Research Hospital
W E Reddick (Author) - St. Jude Children's Research Hospital
Publication details: Magnetic Resonance Imaging, Vol.24(8), pp.1015-1022
Publisher: Elsevier Inc.
Date published: 2006
DOI: 10.1016/j.mri.2006.04.015
ISSN: 0730-725X; 1873-5894; 0730-725X
PMID: 16997071
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99513801102621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Radiology, Nuclear Medicine & Medical Imaging

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