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Magnetic Resonance in Med - 2024 - Foongkajornkiat - Quantitative measurement of mammographic density in breast‐tissue3.67 MB
Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Quantitative measurement of mammographic density in breast-tissue explants using portable NMR: Precision and accuracy
Magnetic Resonance in Medicine, Vol.92(1), pp.374-388
2024
PMID: 38380719
Abstract
Purpose
Single-sided portable NMR (pNMR) has previously been demonstrated to be suitable for quantification of mammographic density (MD) in excised breast tissue samples. Here we investigate the precision and accuracy of pNMR measurements of MD ex vivo as compared with the gold standards.
Methods
Forty-five breast-tissue explants from 9 prophylactic mastectomy patients were measured. The relative tissue water content was taken as the MD-equivalent quantity. In each sample, the water content was measured using some combination of three pNMR techniques (apparent T2, diffusion, and T1 measurements) and two gold-standard techniques (computed microtomography [μCT] and hematoxylin and eosin [H&E] histology). Pairwise correlation plots and Bland–Altman analysis were used to quantify the degree of agreement between pNMR techniques and the gold standards.
Results
Relative water content measured from both apparent T2 relaxation spectra, and diffusion decays exhibited strong correlation with the H&E and μCT results. Bland–Altman analysis yielded average bias values of −0.4, −2.6, 2.6, and 2.8 water percentage points (pp) and 95% confidence intervals of 13.1, 7.5, 11.2, and 11.8 pp for the H&E – T2, μCT – T2, H&E – diffusion, and μCT – diffusion comparison pairs, respectively. T1-based measurements were found to be less reliable, with the Bland–Altman confidence intervals of 27.7 and 33.0 pp when compared with H&E and μCT, respectively.
Conclusion
Apparent T2-based and diffusion-based pNMR measurements enable quantification of MD in breast-tissue explants with the precision of approximately 10 pp and accuracy of approximately 3 pp or better, making pNMR a promising measurement modality for radiation-free quantification of MD.
Details
- Title
- Quantitative measurement of mammographic density in breast-tissue explants using portable NMR: Precision and accuracy
- Authors
- Satcha Foongkajornkiat - Queensland University of TechnologyKamil Sokolowski - Translational Research InstituteJames Stephenson - Princess Alexandra HospitalThomas Lloyd - Princess Alexandra HospitalHonor J. Hugo (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyErik W. Thompson - Queensland University of TechnologyKonstantin I. Momot (Corresponding Author) - Queensland University of Technology
- Publication details
- Magnetic Resonance in Medicine, Vol.92(1), pp.374-388
- Publisher
- John Wiley & Sons, Inc.
- Date published
- 2024
- DOI
- 10.1002/mrm.30040
- ISSN
- 1522-2594; 0740-3194
- PMID
- 38380719
- Copyright note
- © 2024 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Organisation Unit
- School of Health; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 991008898702621
- Output Type
- Journal article
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