Quantifying the effect of body mass index, age, and depression severity on 24-h activity patterns in persons with a lifetime history of affective disorders

N Banihashemi; R Robillard; J Yang; J S Carpenter; Daniel F Hermens; S L Naismith; Z Terpening; D White; E M Scott; I B Hickie

doi:10.1186/s12888-016-1023-2

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Quantifying the effect of body mass index, age, and depression severity on 24-h activity patterns in persons with a lifetime history of affective disorders

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Quantifying the effect of body mass index, age, and depression severity on 24-h activity patterns in persons with a lifetime history of affective disorders

N Banihashemi, R Robillard, J Yang, J S Carpenter, Daniel F Hermens, S L Naismith, Z Terpening, D White, E M Scott and I B Hickie

BMC Psychiatry, Vol.16(1), 317

2016

DOI: https://doi.org/10.1186/s12888-016-1023-2

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Abstract

functional linear model

multiple regression method

body mass index

actigraphy

circadian activity pattern

depression

affective disorders

Background: Patients with affective disorders of different ages have been found to present weight changes and different circadian activity patterns. This study assessed the effects of age, Body Mass Index (BMI) and depression severity on the activity-rest cycle in persons with affective disorders using a novel multifactorial 24-h analysis method. Methods: Two hundred and thirty-six participants aged between 14 and 85 years underwent 5 to 22 days of actigraphy monitoring (mean duration=14 days). BMI was also recorded and symptom severity was assessed with the Hamilton Depression Rating Scale (HDRS). Participants were divided into two groups: healthy controls (n=68) and participants with a lifetime diagnosis of affective disorders (n=168). First, the multiple regression method was employed to formulate the circadian activity pattern in term of the factors age, BMI and HDRS. For each group, the functional linear analysis method was applied to assess the relative effects of the factors. Finally, Wald-tests were used to assess the contribution of each factor on the circadian activity pattern. Results: In the affective disorders group, higher BMI was associated with higher activity levels from 3 am until 5.30 am and with lower activity levels from 10 am until 10.30 pm. Older age was associated with less activity across the day, evening, and night - from 11 am until 5.30 am. Higher HDRS scores were associated with higher activity around 1:30 am. In healthy controls, the effects of BMI and age on activity patterns were less pronounced and affected a narrower portion of the 24-h period. Conclusion: These findings suggest that older age and higher BMI are linked to lower daytime activity levels. Higher BMI and worse symptom severity were also associated with nocturnal activity patterns suggestive of sleep disturbances. The influence of age and BMI on 24-h activity profiles appear to be especially pronounced in people with affective disorders. © 2016 The Author(s).

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Title: Quantifying the effect of body mass index, age, and depression severity on 24-h activity patterns in persons with a lifetime history of affective disorders
Authors: N Banihashemi (Author) - University of Sydney
R Robillard (Author) - University of Sydney
J Yang (Author) - University of Sydney
J S Carpenter (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
S L Naismith (Author) - University of Sydney
Z Terpening (Author) - University of Sydney
D White (Author) - University of Sydney
E M Scott (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Publication details: BMC Psychiatry, Vol.16(1), 317
Publisher: BioMed Central Ltd.
Date published: 2016
DOI: 10.1186/s12888-016-1023-2
ISSN: 1471-244X
Copyright note: Copyright © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450592602621
Output Type: Journal article

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