Putative biomarker of working memory systems development during childhood and adolescence

H A D Keage; C R Clark; Daniel F Hermens; L M Williams; M R Kohn; S Clarke; C Lamb; D Crewther; E Gordon

doi:10.1097/WNR.0b013e3282f454af

Back

Putative biomarker of working memory systems development during childhood and adolescence

Journal article

Peer reviewed

Putative biomarker of working memory systems development during childhood and adolescence

H A D Keage, C R Clark, Daniel F Hermens, L M Williams, M R Kohn, S Clarke, C Lamb, D Crewther and E Gordon

NeuroReport, Vol.19(2), pp.197-201

2008

DOI: https://doi.org/10.1097/WNR.0b013e3282f454af

Files and links (1)

url

https://doi.org/10.1097/WNR.0b013e3282f454afView

Published Version

Abstract

The study aimed to identify brain functional indicators of working memory systems development between 6 and 18 years. Event-related potentials (ERPs) were recorded from 251 normally developing children to stimuli requiring the updating of working memory. Cluster analysis of event-related potential componentry divided the sample into three clusters (mean ages 9, 12 and 16 years), with ascending cluster membership independently associated with improved task performance. The clusters correspond to periods of grey matter loss and white matter increase observed in developing children, supporting the view that the clusters delineate three key qualitative stages in advancing cognitive capability during the maturation of higher brain systems function. This outcome identifies a biomarker with the potential for assessing abnormalities in the rate of brain development. © 2008 Lippincott Williams &Wilkins, Inc.

Details

Title: Putative biomarker of working memory systems development during childhood and adolescence
Authors: H A D Keage (Author) - Flinders University
C R Clark (Author) - Flinders University
Daniel F Hermens (Author) - University of Sydney
L M Williams (Author) - University of Sydney
M R Kohn (Author) - Westmead Hospital
S Clarke (Author) - Westmead Hospital
C Lamb (Author) - Flinders University
D Crewther (Author) - Swinburne University
E Gordon (Author) - University of Sydney
Publication details: NeuroReport, Vol.19(2), pp.197-201
Publisher: Lippincott Williams & Wilkins
Date published: 2008
DOI: 10.1097/WNR.0b013e3282f454af
ISSN: 0959-4965
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450452602621
Output Type: Journal article

Metrics

206 Record Views

4 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Web Of Science research areas: Neurosciences

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites