Journal article
Protective Effects of Bacteriophages against Aeromonas hydrophila Causing Motile Aeromonas Septicemia (MAS) in Striped Catfish
Antibiotics, Vol.7(1), 16
2018
Abstract
To determine the effectivity of bacteriophages in controlling the mass mortality of striped catfish (Pangasianodon hypophthalmus) due to infections caused by Aeromonas spp. in Vietnamese fish farms, bacteriophages against pathogenic Aeromonas hydrophila were isolated. A. hydrophila-phage 2 and A. hydrophila-phage 5 were successfully isolated from water samples from the Saigon River of Ho Chi Minh City, Vietnam. These phages, belonging to the Myoviridae family, were found to have broad activity spectra, even against the tested multiple-antibiotic-resistant Aeromonas isolates. The latent periods and burst size of phage 2 were 10 min and 213 PFU per infected host cell, respectively. The bacteriophages proved to be effective in inhibiting the growth of the Aeromonas spp. under laboratory conditions. Phage treatments applied to the pathogenic strains during infestation of catfish resulted in a significant improvement in the survival rates of the tested fishes, with up to 100% survival with MOI 100, compared to 18.3% survival observed in control experiments. These findings illustrate the potential for using phages as an effective bio-treatment method to control Motile Aeromonas Septicemia (MAS) in fish farms. This study provides further evidence towards the use of bacteriophages to effectively control disease in aquaculture operations.
Details
- Title
- Protective Effects of Bacteriophages against Aeromonas hydrophila Causing Motile Aeromonas Septicemia (MAS) in Striped Catfish
- Authors
- Tuan Son Le (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringThi Hien Nguyen (Author) - Research Institute for Aquaculture No. 2, VietnamHong Phuong Vo (Author) - Research Institute for Aquaculture No. 2, VietnamVan Cuong Doan (Author) - Research Institute for Aquaculture No. 2, VietnamHong Loc Nguyen (Author) - Research Institute for Aquaculture No. 2, VietnamMinh Trung Tran (Author) - Research Institute for Aquaculture No. 2, VietnamPaul C Southgate (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringD Ipek Kurtboke (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- Antibiotics, Vol.7(1), 16; 11
- Publisher
- MDPI AG
- Date published
- 2018
- DOI
- 10.3390/antibiotics7010016
- ISSN
- 2079-6382
- Copyright note
- Copyright © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Science and Engineering - Legacy; Australian Centre for Pacific Islands Research; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450897702621
- Output Type
- Journal article
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- Collaboration types
- International collaboration
- Web Of Science research areas
- Infectious Diseases
- Pharmacology & Pharmacy