Prostate cancer outcome and tissue levels of metal ions

A Sarafanov; T Todorov; J Centeno; V Macias; W Gao; W-M Liang; C Beam; Marion Gray; A Kajdacsy-Balla

doi:10.1002/pros.21339

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Prostate cancer outcome and tissue levels of metal ions

Journal article

Peer reviewed

Prostate cancer outcome and tissue levels of metal ions

A Sarafanov, T Todorov, J Centeno, V Macias, W Gao, W-M Liang, C Beam, Marion Gray and A Kajdacsy-Balla

The Prostate, Vol.71(11), pp.1231-1238

2011

DOI: https://doi.org/10.1002/pros.21339

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Abstract

PSA recurrence

zinc

iron

selenium

cadmium

BACKGROUND There are several studies examining prostate cancer and exposure to cadmium, iron, selenium, and zinc. Less data are available on the possible influence of these metal ions on prostate cancer outcome. This study measured levels of these ions in prostatectomy samples in order to examine possible associations between metal concentrations and disease outcome. METHODS We obtained formalin fixed paraffin embedded tissue blocks of prostatectomy samples of 40 patients with PSA recurrence, matched 1:1 (for year of surgery, race, age, Gleason grading, and pathology TNM classification) with tissue blocks from 40 patients without recurrence (n = 80). Case–control pairs were compared for the levels of metals in areas adjacent to tumors. Inductively coupled plasma‐mass spectrometry (ICP‐MS) was used for quantification of Cd, Fe, Zn, and Se. RESULTS Patients with biochemical (PSA) recurrence of disease had 12% lower median iron (95 µg/g vs. 111 µg/g; P = 0.04) and 21% lower zinc (279 µg/g vs. 346 µg/g; P = 0.04) concentrations in the normal‐appearing tissue immediately adjacent to cancer areas. Differences in cadmium (0.489 µg/g vs. 0.439 µg/g; 4% higher) and selenium (1.68 µg/g vs. 1.58 µg/g; 5% higher) levels were not statistically significant in recurrence cases, when compared to non‐recurrences (P = 0.40 and 0.21, respectively). CONCLUSIONS There is an association between low zinc and low iron prostate tissue levels and biochemical recurrence in prostate cancer. Whether these novel findings are a cause or effect of more aggressive tumors, or whether low zinc and iron prostatic levels raise implications for therapy, remains to be investigated.

Details

Title: Prostate cancer outcome and tissue levels of metal ions
Authors: A Sarafanov (Author) - Armed Forces Institute of Pathology, United States
T Todorov (Author) - CGGSC Denver, United States
J Centeno (Author) - Armed Forces Institute of Pathology, United States
V Macias (Author) - University of Illinois, United States
W Gao (Author) - University of Illinois, United States
W-M Liang (Author) - University of Illinois, United States
C Beam (Author) - University of Illinois, United States
Marion Gray (Author) - James Cook University
A Kajdacsy-Balla (Author) - University of Illinois, United States
Publication details: The Prostate, Vol.71(11), pp.1231-1238
Publisher: John Wiley & Sons Inc.
Date published: 2011
DOI: 10.1002/pros.21339
ISSN: 0270-4137
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99450261202621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Endocrinology & Metabolism; Urology & Nephrology

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