Journal article
Prolactin levels in antipsychotic treatment of patients with schizophrenia carrying the DRD2A1 allele
British Journal of Psychiatry, Vol.185(2), pp.147-151
2004
PMID: 15286066
Abstract
Background:
Hyperprolactinaemia induced by D2 dopamine receptor antagonist antipsychotic medication can result in significant health problems.
Aims:
To examine the role of DRD2 polymorphism on prolactin levels in patients treated with antipsychotic medication.
Method:
Antipsychotic drugs with different degrees of D2 receptor binding were given to 144 patients with schizophrenia. Serum prolactin levels were obtained and Taq1A DRD2 alleles were determined.
Results:
Prolactin levels increased across medication groups reflecting increasingly tight D2 receptor binding (clozapine, olanzapine, typical antipsychotics and risperidone). In the combined medication group, patients with the DRD2∗A1 allele had 40% higher prolactin levels than patients without this allele. In patients treated with clozapine (the loosest D2 receptor binding agent), patients with the DRD2∗A1 allele had prolactin levels twice those of patients without this allele.
Conclusions:
Patients with the DRD2A1 allele receiving antipsychotic medications had higher prolactin levels and were overrepresented among those with hyperprolactinaemia, suggesting greater functional D2 receptor binding in this group.
Details
- Title
- Prolactin levels in antipsychotic treatment of patients with schizophrenia carrying the DRD2A1 allele
- Authors
- Ross Young (Author) - Queensland University of TechnologyBruce R Lawford (Author) - University of California Los AngelesMark Barnes (Author) - Royal Brisbane HospitalSimon C Burton (Author) - Royal Brisbane HospitalTerry Ritchie (Author) - University of California Los AngelesWarren K Ward (Author) - Royal Brisbane HospitalErnest P Noble (Author) - University of California Los Angeles
- Publication details
- British Journal of Psychiatry, Vol.185(2), pp.147-151; 5
- Publisher
- Cambridge University Press
- DOI
- 10.1192/bjp.185.2.147
- ISSN
- 1472-1465
- PMID
- 15286066
- Organisation Unit
- Office of the Deputy Vice-Chancellor (Research and Innovation); University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99550991602621
- Output Type
- Journal article
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- Domestic collaboration
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- Psychiatry
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Source: InCites