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Submitted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Progress towards understanding the genetics of posttraumatic stress disorder
Journal of Anxiety Disorders, Vol.28(8), pp.873-883
2014
PMID: 25445077
Abstract
Posttraumatic stress disorder (PTSD) is a complex syndrome that occurs following exposure to a potentially life threatening traumatic event. This review summarises the literature on the genetics of PTSD including gene-environment interactions (GxE), epigenetics and genetics of treatment response. Numerous genes have been shown to be associated with PTSD using candidate gene approaches. Genome-wide association studies have been limited due to the large sample size required to reach statistical power. Studies have shown that GxE interactions are important for PTSD susceptibility. Epigenetics plays an important role in PTSD susceptibility and some of the most promising studies show stress and child abuse trigger epigenetic changes. Much of the molecular genetics of PTSD remains to be elucidated. However, it is clear that identifying genetic markers and environmental triggers has the potential to advance early PTSD diagnosis and therapeutic interventions and ultimately ease the personal and financial burden of this debilitating disorder.
Details
- Title
- Progress towards understanding the genetics of posttraumatic stress disorder
- Authors
- Joanne Voisey (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of TechnologyBruce R Lawford (Author) - Queensland University of TechnologyCharles P Morris (Author) - Queensland University of Technology
- Publication details
- Journal of Anxiety Disorders, Vol.28(8), pp.873-883
- Publisher
- Elsevier Ltd
- Date published
- 2014
- DOI
- 10.1016/j.janxdis.2014.09.014
- ISSN
- 1873-7897; 0887-6185
- PMID
- 25445077
- Copyright note
- Copyright © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551705802621
- Output Type
- Journal article
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- Psychiatry
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