Production and secretion of thioredoxin from transformed human trophoblast cells

G.Di Trapani; A Perkins; F Clarke

doi:10.1093/molehr/4.4.369

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Production and secretion of thioredoxin from transformed human trophoblast cells

Journal article

Peer reviewed

Production and secretion of thioredoxin from transformed human trophoblast cells

G.Di Trapani, A Perkins and F Clarke

Molecular Human Reproduction, Vol.4(4), pp.369-375

1998

DOI: https://doi.org/10.1093/molehr/4.4.369

PMID: 9620837

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Abstract

cytokine

oxidative stress

pregnancy

bodily secretions

cell lines

mothers

oxidation-reduction

reproductive physiological process

thioredoxin

trophoblasts

placenta

cytotrophoblast

cell injury

prevention

fetal endoscopic tracheal occlusion

Thioredoxin is a redox active protein which has been implicated in reproductive processes. In this study we investigated the intracellular production and extracellular secretion of placental thioredoxin by human cytotrophoblast cell lines which were used as in-vitro model systems. Results clearly demonstrated that thioredoxin is not only synthesized by these cells but is also secreted and that while the intracellular thioredoxin is present only as a 12 kDa form, it would appear that the extracellular thioredoxin is present in two forms, a predominant 12 kDa form accompanied by a lower amount of a 10 kDa form. The observed localization and possible secretion of thioredoxin at the feto-maternal interface suggest important roles for this protein during pregnancy. Intracellular thioredoxin may be involved in the prevention of cellular damage due to oxidative stress whereas extracellular thioredoxin may act to integrate the actions of the cytokine network operating at the feto-maternal interface thereby assisting with implantation and the successful establishment of pregnancy.

Details

Title: Production and secretion of thioredoxin from transformed human trophoblast cells
Authors: G.Di Trapani (Author) - Griffith University
A Perkins (Author) - Griffith University
F Clarke (Author) - Griffith University
Publication details: Molecular Human Reproduction, Vol.4(4), pp.369-375
Publisher: Oxford University Press
DOI: 10.1093/molehr/4.4.369
ISSN: 1460-2407
PMID: 9620837
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
Language: English
Record Identifier: 99685296102621
Output Type: Journal article

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Web Of Science research areas: Developmental Biology; Obstetrics & Gynecology; Reproductive Biology

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