Journal article
Prevalence of mental disorders among people with opioid use disorder: A Systematic Review and Meta-analysis
Drug and Alcohol Dependence, Vol.238, pp.1-11
2022
Abstract
Background:
Opioid use disorder (OUD) and mental disorders are major public health issues and comorbidity is common. Among people with OUD, comorbid mental disorders are associated with poorer health outcomes. To our knowledge, this is the first systematic review and meta-analysis to estimate prevalence of specific mental disorders among people with OUD.
Methods:
We searched Embase, MEDLINE, and PsycInfo from 1990-2021 for observational studies of depression, anxiety, bipolar, personality, and other pre-specified mental disorders among people with OUD. We pooled current and lifetime estimates of each disorder using random-effects meta-analyses with 95% Confidence Intervals (CIs). Meta-regressions and stratified analyses were used to assess heterogeneity of prevalence estimates by methodological factors and sample characteristics.
Findings:
Of the 36,971 publications identified, we included data from 345 studies and 104,135 people with OUD in at least one pooled estimate. Among people with OUD, the prevalence of current depression was 36.1% (95%CI 32.4-39.7%), anxiety was 29.1% (95%CI 24.0-33.3%), attention-deficit/hyperactivity disorder was 20.9% (95%CI 15.7–26.2%), post-traumatic stress disorder was 18.1% (95%CI 15.4-20.9%), and bipolar disorder was 8.7% (95%CI 6.7-10.7%). Lifetime prevalence of anti-social personality disorder was 33.6% (95%CI 29.1-38.0%) and borderline personality disorder was 18.2% (95% CI 13.4-23.1%). Sample characteristics and methodological factors, including sex, were associated with variance of multiple prevalence estimates.
Interpretation:
Our findings emphasise the need for access to mental disorder treatment among people with OUD. Specific mental disorder estimates may inform clinical guidelines, treatment services, and future research for people with OUD, including subpopulations with distinct treatment needs.
Details
- Title
- Prevalence of mental disorders among people with opioid use disorder: A Systematic Review and Meta-analysis
- Authors
- Thomas Santo (Author) - UNSW AustraliaGabrielle Campbell (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyNatasa Gisev (Author) - UNSW AustraliaDaniel Martino-Burke (Author) - UNSW AustraliaJack Wilson (Author) - University of SydneySamantha Colledge (Author) - UNSW AustraliaBrodie Clark (Author) - UNSW AustraliaLucy Thi Tran (Author) - UNSW AustraliaLouisa Degenhardt (Author) - UNSW Australia
- Publication details
- Drug and Alcohol Dependence, Vol.238, pp.1-11
- Publisher
- Elsevier Ireland Ltd.
- Date published
- 2022
- DOI
- 10.1016/j.drugalcdep.2022.109551
- ISSN
- 1879-0046
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99652298202621
- Output Type
- Journal article
Metrics
54 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Psychiatry
- Substance Abuse
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites