Files and links (1)
Published VersionCC BY V4.0, Open Access
Journal article
Prenatal maternal stress predicts childhood asthma in girls: project ice storm
BioMed Research International, Vol.2014, pp.1-10
2014
PMID: 24895550
Abstract
Little is known about how prenatal maternal stress (PNMS) influences risks of asthma in humans. In this small study, we sought to determine whether disaster-related PNMS would predict asthma risk in children. In June 1998, we assessed severity of objective hardship and subjective distress in women pregnant during the January 1998 Quebec Ice Storm. Lifetime asthma symptoms, diagnoses, and corticosteroid utilization were assessed when the children were 12 years old (N = 68). No effects of objective hardship or timing of the exposure were found. However, we found that, in girls only, higher levels of prenatal maternal subjective distress predicted greater lifetime risk of wheezing (OR = 1.11; 90% CI = 1.01-1.23), doctor-diagnosed asthma (OR = 1.09; 90% CI = 1.00-1.19), and lifetime utilization of corticosteroids (OR = 1.12; 90% CI = 1.01-1.25). Other perinatal and current maternal life events were also associated with asthma outcomes. Findings suggest that stress during pregnancy opens a window for fetal programming of immune functioning. A sex-based approach may be useful to examine how prenatal and postnatal environments combine to program the immune system. This small study needs to be replicated with a larger, more representative sample.
Details
- Title
- Prenatal maternal stress predicts childhood asthma in girls: project ice storm
- Authors
- Anne-Marie Turcotte-Tremblay - Douglas Mental Health University InstituteRobert Lim - Harvard UniversityDavid P Laplante - Douglas Mental Health University InstituteLester Kobzik - Harvard UniversityAlain Brunet - Douglas Mental Health University InstituteSuzanne King (Corresponding Author) - Douglas Mental Health University Institute
- Publication details
- BioMed Research International, Vol.2014, pp.1-10
- Publisher
- John Wiley & Sons Ltd.
- Date published
- 2014
- DOI
- 10.1155/2014/201717
- ISSN
- 2314-6141; 2314-6133
- PMID
- 24895550
- Copyright note
- Copyright © 2014 Anne-Marie Turcotte-Tremblay et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Grant note
- This study was funded by the Stairs Memorial Fund of McGill University, by the Canadian Institutes of Health Research (MOP-57849, MOP-79424, MOP-93660, and MOP-111177, (Suzanne King, the Principal Investigator, and David P. Laplante)), and NIH ES 017588 (Lester Kobzik and Robert Lim). Anne-Marie Turcotte-Tremblay is funded by the University of Montreal Hospital Research Center and the University of Montreal Public Health Research Institute.
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 991105746202621
- Output Type
- Journal article
Metrics
1 File views/ downloads
21 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Biotechnology & Applied Microbiology
- Medicine, Research & Experimental
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites