Journal article
Pregnancy in aged rats that were born small: cardiorenal and metabolic adaptations and second-generation fetal growth
The FASEB journal, Vol.26(10), pp.4337-4347
2012
PMID: 22772163
Abstract
Uteroplacental insufficiency is associated with adult cardiorenal and metabolic diseases, particularly in males. Pregnancy is the greatest physiological challenge facing women, and those born small are at increased risk of gestational hypertension and diabetes and delivering smaller babies. Increased maternal age is associated with exacerbated pregnancy complications. We hypothesized that pregnancy in aged, growth-restricted females unmasks an underlying predisposition to cardiorenal and metabolic dysfunction and compromises fetal growth. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (restricted group) or sham surgery (control group) on d 18 of gestation in Wistar Kyoto rats. At 12 mo, growth-restricted F1 female offspring were mated with a normal male. F1 restricted females had elevated systolic blood pressure, before and during pregnancy (+10 mmHg) but normal renal and metabolic pregnancy adaptations. F2 fetal weight was not different between groups. In control and restricted females, advanced maternal age (12 vs. 4 mo) was associated with a reduction in the hypoglycemic response to pregnancy and reduced F2 fetal litter size and body weight. Aged rats born small exhibited mostly normal pregnancy adaptations, although they had elevated blood pressure. Advanced maternal age was associated with poorer fetal outcomes that were not exacerbated by low maternal birth weight.-Gallo, L. A., Tran, M., Moritz, K. M., Jefferies, A. J., Wlodek, M. E. Pregnancy in aged rats that were born small: cardiorenal and metabolic adaptations and second-generation fetal growth. FASEB J. 26, 4337-4347 (2012). www.fasebj.org
Details
- Title
- Pregnancy in aged rats that were born small: cardiorenal and metabolic adaptations and second-generation fetal growth
- Authors
- Linda A. Gallo (Author) - University of MelbourneMelanie Tran (Author) - University of MelbourneKaren M. Moritz (Author) - University of QueenslandAndrew J. Jefferies (Author) - University of MelbourneMary E. Wlodek (Corresponding Author) - University of Melbourne
- Publication details
- The FASEB journal, Vol.26(10), pp.4337-4347
- Publisher
- John Wiley & Sons, Inc.
- DOI
- 10.1096/fj.12-210401
- ISSN
- 1530-6860
- PMID
- 22772163
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99679193702621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Biology
- Cell Biology
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Source: InCites