Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities

Sergio Quinones-Parra; Emma Grant; Liyen Loh; Thi H O Nguygen; Kristy-Anne Campbell; Steven Y C Tong; Adrian Miller; Peter C Doherty; Dhanasekaran Vijaykrishna; Jamie Rossjohn; Stephanie Gras; Katherine Kedzierska

doi:10.1073/pnas.1322229111

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Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities

Journal article

Open access

Peer reviewed

Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities

Sergio Quinones-Parra, Emma Grant, Liyen Loh, Thi H O Nguygen, Kristy-Anne Campbell, Steven Y C Tong, Adrian Miller, Peter C Doherty, Dhanasekaran Vijaykrishna, Jamie Rossjohn, …

Proceedings of the National Academy of Sciences of the United States of America, Vol.111(3), pp.1049-1054

2014

DOI: https://doi.org/10.1073/pnas.1322229111

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Abstract

CD8 T cells

HLA types

The absence of preexisting neutralizing antibodies specific for the novel A (H7N9) influenza virus indicates a lack of prior human exposure. As influenza A virus-specific CD8+ T lymphocytes (CTLs) can be broadly cross-reactive, we tested whether immunogenic peptides derived from H7N9 might be recognized by memory CTLs established following infection with other influenza strains. Probing across multiple ethnicities, we identified 32 conserved epitopes derived from the nucleoprotein (NP) and matrix-1 (M1) proteins. These NP and M1 peptides are presented by HLAs prevalent in 16-57% of individuals. Remarkably, some HLA alleles (A*0201, A*0301, B*5701, B*1801, and B*0801) elicit robust CTL responses against any human influenza A virus, including H7N9, whereas ethnicities where HLA-A*0101, A*6801, B*1501, and A*2402 are prominent, show limited CTL response profiles. By this criterion, some groups, especially the Alaskan and Australian Indigenous peoples, would be particularly vulnerable to H7N9 infection. This dissection of CTL-mediated immunity to H7N9 thus suggests strategies for both vaccine delivery and development.

Details

Title: Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities
Authors: Sergio Quinones-Parra (Author) - The University of Melbourne
Emma Grant (Author) - The University of Melbourne
Liyen Loh (Author) - The University of Melbourne
Thi H O Nguygen (Author) - The University of Melbourne
Kristy-Anne Campbell (Author) - Monash University
Steven Y C Tong (Author) - Charles Darwin University
Adrian Miller (Author) - Griffith University
Peter C Doherty (Corresponding Author) - The University of Melbourne
Dhanasekaran Vijaykrishna (Author) - Duke-NUS Medical School
Jamie Rossjohn (Author) - Monash University
Stephanie Gras (Author) - Monash University
Katherine Kedzierska (Corresponding Author) - The University of Melbourne
Publication details: Proceedings of the National Academy of Sciences of the United States of America, Vol.111(3), pp.1049-1054
Publisher: National Academy of Sciences
Date published: 2014
DOI: 10.1073/pnas.1322229111
ISSN: 0027-8424
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99448962802621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Immunology

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