Logo image
Back
Preexercise Aminoacidemia and Muscle Protein Synthesis after Resistance Exercise
Journal article   Peer reviewed

Preexercise Aminoacidemia and Muscle Protein Synthesis after Resistance Exercise

L M Burke, J A Hawley, M L Ross, D R Moore, S M Phillips, Gary J Slater, T Stellingwerff, K D Tipton, A P Garnham and V G Coffey
Medicine and Science in Sports and Exercise, Vol.44(10), pp.1968-1977
2012
DOI: https://doi.org/10.1249/MSS.0b013e31825d28fa
PMID: 22617396
url
https://doi.org/10.1249/MSS.0b013e31825d28faView
Published Version

Abstract

amino acid delivery fast and slow proteins muscle protein synthesis leucine
PURPOSE: We have previously shown that the aminoacidemia caused by the consumption of a rapidly digested protein after resistance exercise enhances muscle protein synthesis (MPS) more than the amino acid (AA) profile associated with a slowly digested protein. Here, we investigated whether differential feeding patterns of a whey protein mixture commencing prior to exercise affect post-exercise intracellular signaling and muscle protein synthesis (MPS). METHODS: Twelve resistance-trained males performed leg resistance exercise 45 min after commencing each of three volume-matched nutrition protocols: placebo (PLAC; artificially sweetened water); BOLUS (25 g whey protein + 5 g leucine dissolved in artificially sweetened water; 1 × 500 mL); or PULSE (15 × 33 mL aliquots of BOLUS drink every 15 min). RESULTS: The pre-exercise rise in plasma AA concentration with PULSE was attenuated compared with BOLUS (P less than 0.05); this effect was reversed following exercise, with two-fold greater leucine concentrations in PULSE compared to BOLUS (P less than 0.05). One-hour post-exercise, phosphorylation of p70 S6K and rpS6 was increased above baseline with BOLUS and PULSE, but not PLAC (P less than 0.05); furthermore, PULSE more than BOLUS (P less than 0.05). MPS throughout 5 h of recovery was higher with protein ingestion compared with PLAC (0.037 ±0.007) with no differences between BOLUS or PULSE (0.085 ±0.013 vs 0.095 ±0.010 %·h respectively, P = 0.56).CONCLUSIONS: Manipulation of aminoacidemia prior to resistance exercise via different patterns of intake of protein, altered plasma AA profiles and post-exercise intracellular signaling. However, there was no difference in the enhancement of the muscle protein synthetic response after exercise. Protein sources producing a slow AA release, when consumed before resistance exercise in sufficient amounts, are as effective as rapidly digested proteins in promoting post-exercise muscle protein synthesis.

Details

Metrics

6 File views/ downloads
942 Record Views
65 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Industry collaboration
Domestic collaboration
International collaboration
Web Of Science research areas
Sport Sciences

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#2 Zero Hunger
#3 Good Health and Well-Being
#5 Gender Equality

Source: InCites

Logo image