Predicting stimulant medication response in ADHD: Evidence from an integrated profile of neuropsychological, psychophysiological and clinical factors

Daniel F Hermens; N J Cooper; M Kohn; S Clarke; E Gordon; L M Williams

doi:10.1142/S0219635205000653

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Predicting stimulant medication response in ADHD: Evidence from an integrated profile of neuropsychological, psychophysiological and clinical factors

Daniel F Hermens, N J Cooper, M Kohn, S Clarke, E Gordon and L M Williams

Journal of Integrative Neuroscience, Vol.4(1), pp.107-121

2005

DOI: https://doi.org/10.1142/S0219635205000653

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Abstract

attention-deficit/hyperactivity disorder (ADHD)

psychophysiology

neuropsychology

stimulant medication prediction

There have been significant advances in understanding the neurobiology of Attention-Deficit/Hyperactivity Disorder (ADHD) and it is timely to examine the ability of biological and psychological markers to predict medication response in this disorder. We evaluated prediction of medication response in adolescent ADHD using neuropsychological testing and psychophysiological measures of central and autonomic function. Fifty ADHD adolescents participated in pre- and post-stimulant medication testing. Separately ranked performance in auditory oddball and visual Working Memory (WM) tasks determined 20 "responders" and 20 "non-responders", with 10 "neutrals" excluded from the discriminant function analyses (DFA). For both oddball and WM performance rankings, the two groups did not differ in age, sex, or handedness. However, responders did have higher levels of symptomatology than non-responders at baseline. Pre-stimulant medication psychophysiology variables were used as predictors in each DFA. Oddball performance correctly classified 85.0% of responders and 95.0% of non-responders. Better response was associated with increased resting beta power (left posteriorly), delayed oddball target N1 (frontally), decreased oddball target P2 (left posteriorly) and decreased WM distractor P3 (right frontally). Working memory performance classified 80.0% of responders and 90.0% of non-responders, with a broadly similar profile of psychophysiological predictors. These findings indicate the value of integrating neuropsychological and psychophysiological data in predicting medication response in ADHD. © Imperial College Press.

Details

Title: Predicting stimulant medication response in ADHD: Evidence from an integrated profile of neuropsychological, psychophysiological and clinical factors
Authors: Daniel F Hermens (Author) - University of Sydney
N J Cooper (Author) - Brain Resource Company
M Kohn (Author) - University of Sydney
S Clarke (Author) - University of Sydney
E Gordon (Author) - University of Sydney
L M Williams (Author) - University of Sydney
Publication details: Journal of Integrative Neuroscience, Vol.4(1), pp.107-121
Publisher: IOS Press
Date published: 2005
DOI: 10.1142/S0219635205000653
ISSN: 0219-6352
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451205002621
Output Type: Journal article

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