Predator or prey? Chlamydophila abortus infections of a free-living amoebae, Acanthamoeba castellani 9GU

M Wirz; Adam Polkinghorne; C Dumrese; U Ziegler; G Greub; A Pospischil; L Vaughan

doi:10.1016/j.micinf.2008.01.006

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Predator or prey? Chlamydophila abortus infections of a free-living amoebae, Acanthamoeba castellani 9GU

Journal article

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Predator or prey? Chlamydophila abortus infections of a free-living amoebae, Acanthamoeba castellani 9GU

M Wirz, Adam Polkinghorne, C Dumrese, U Ziegler, G Greub, A Pospischil and L Vaughan

Microbes and Infection, Vol.10(6), pp.591-597

2008

DOI: https://doi.org/10.1016/j.micinf.2008.01.006

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Abstract

Limited evidence exists to suggest that the ability to invade and escape protozoan host cell bactericidal activity extends to members of the Chlamydiaceae, intracellular pathogens of humans and animals and evolutionary descendants of amoeba-resisting Chlamydia-like organisms. PCR and microscopic analyses of Chlamydophila abortus infections of Acanthamoeba castellani revealed uptake of this chlamydial pathogen but, unlike the well-described inhabitant of A. castellani, Parachlamydia acanthamoebae, Cp. abortus did not appear to propagate and is likely digested by its amoebal host. These data raise doubts about the ability of free-living amoebae to serve as hosts and vectors of pathogenic members of the Chlamydiaceae but reveal opportunities, via comparative genomics, to understand virulence mechanisms used by Chlamydia-like organisms to avoid amoebal digestion. © 2008 Elsevier Masson SAS. All rights reserved.

Details

Title: Predator or prey? Chlamydophila abortus infections of a free-living amoebae, Acanthamoeba castellani 9GU
Authors: M Wirz (Author) - University of Zurich, Switzerland
Adam Polkinghorne (Author) - University of Zurich, Switzerland
C Dumrese (Author) - University of Zurich, Switzerland
U Ziegler (Author) - University of Zurich, Switzerland
G Greub (Author) - University of Lausanne, Switzerland
A Pospischil (Author) - University of Zurich, Switzerland
L Vaughan (Author) - University of Zurich, Switzerland
Publication details: Microbes and Infection, Vol.10(6), pp.591-597
Publisher: Elsevier Masson
Date published: 2008
DOI: 10.1016/j.micinf.2008.01.006
ISSN: 1286-4579
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449207302621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology

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