Potentiometric detection of DNA hybridization

A Numnuam; K Y Chumbimuni-Torres; Y Xiang; R Bash; P Thavarungkul; P Kanatharana; E Pretsch; J Wang; Eric Bakker

doi:10.1021/ja0775467

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Potentiometric detection of DNA hybridization

Journal article

Open access

Peer reviewed

Potentiometric detection of DNA hybridization

A Numnuam, K Y Chumbimuni-Torres, Y Xiang, R Bash, P Thavarungkul, P Kanatharana, E Pretsch, J Wang and Eric Bakker

Journal of the American Chemical Society, Vol.130(2), pp.410-411

2008

DOI: https://doi.org/10.1021/ja0775467

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Abstract

ion-selective electrodes

electrochemical detection

nanoparticle tags

oligonucleotide

microelectrodes

biosensor

targets

labels

level

The use of potentiometric microsensors is demonstrated here for the first time to detect DNA hybridization. Cadmium sulfide nanocrystal labels bound on a secondary oligonucleolide are dissolved and detected with cadmium-selective microelectrodes exhibiting DNA detection limits of ca. 2 fmol in a 200 mu sample.

Details

Title: Potentiometric detection of DNA hybridization
Authors: A Numnuam (Author) - Purdue University, United States
K Y Chumbimuni-Torres (Author) - Purdue University, United States
Y Xiang (Author) - Arizona State University, United States
R Bash (Author) - Arizona State University, United States
P Thavarungkul (Author) - Prince of Songkla University, Thailand
P Kanatharana (Author) - Prince of Songkla University, Thailand
E Pretsch (Author) - ETH Zu¨rich, Switzerland
J Wang (Author) - Arizona State University, United States
Eric Bakker (Author) - Curtin University
Publication details: Journal of the American Chemical Society, Vol.130(2), pp.410-411
Publisher: American Chemical Society
Date published: 2008
DOI: 10.1021/ja0775467
ISSN: 0002-7863
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450251002621
Output Type: Journal article

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Web Of Science research areas: Chemistry, Multidisciplinary

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