Potent cytotoxic peptides from the Australian marine sponge Pipestela candelabra

Trong D Tran; N B Pham; G A Fechner; J N A Hooper; R J Quinn

doi:10.3390/md12063399

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Potent cytotoxic peptides from the Australian marine sponge Pipestela candelabra

Journal article

Open access

Peer reviewed

Potent cytotoxic peptides from the Australian marine sponge Pipestela candelabra

Trong D Tran, N B Pham, G A Fechner, J N A Hooper and R J Quinn

Marine Drugs, Vol.12(6), pp.3399-3415

2014

DOI: https://doi.org/10.3390/md12063399

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Abstract

pipestela candelabra

cytotoxicity

peptide

milnamide

hemiasterlin

geodiamolide

prostate cancer

Two consecutive prefractionated fractions of the Australian marine sponge extract, Pipestela candelabra, were identified to be selectively active on the human prostate cancer cells (PC3) compared to the human neonatal foreskin fibroblast non-cancer cells (NFF). Twelve secondary metabolites were isolated in which four compounds are new small peptides. Their structures were characterized by spectroscopic and chemical analysis. These compounds inhibited selectively the growth of prostate cancer cells with IC50 values in the picomolar to sub-micromolar range. Structure-activity relationship of these compounds is discussed. © 2014 by the authors licensee MDPI.

Details

Title: Potent cytotoxic peptides from the Australian marine sponge Pipestela candelabra
Authors: Trong D Tran (Author) - Griffith University
N B Pham (Author) - Griffith University
G A Fechner (Author) - Griffith University
J N A Hooper (Author) - Griffith University
R J Quinn (Author) - Griffith University
Publication details: Marine Drugs, Vol.12(6), pp.3399-3415
Publisher: MDPI AG
Date published: 2014
DOI: 10.3390/md12063399
ISSN: 1660-3397
Copyright note: Copyright © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450593802621
Output Type: Journal article

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