Potent Antibacterial Prenylated Acetophenones from the Australian Endemic Plant Acronychia crassipetala

Trong D Tran; Malin A Olsson; David J McMillan; Jason K Cullen; Peter G Parsons; Paul W Reddell; Steven M Ogbourne

doi:10.3390/antibiotics9080487

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Potent Antibacterial Prenylated Acetophenones from the Australian Endemic Plant Acronychia crassipetala

Journal article

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Potent Antibacterial Prenylated Acetophenones from the Australian Endemic Plant Acronychia crassipetala

Trong D Tran, Malin A Olsson, David J McMillan, Jason K Cullen, Peter G Parsons, Paul W Reddell and Steven M Ogbourne

Antibiotics, Vol.9(8), pp.1-9

2020

DOI: https://doi.org/10.3390/antibiotics9080487

PMCID: PMC7460405

PMID: 32781771

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Abstract

Acronychia crassipetala

prenylated acetophenone

crassipetalone A

crassipetalonol A

antibiotics

cytotoxicity

Acronychia crassipetala is an endemic plant species in Australia. Its phytochemistry and therapeutic properties are underexplored. The hexane extract of the fruit A. crassipetala T. G. Hartley was found to inhibit the growth of the Gram-positive bacteria Staphylococcus aureus. Following bio-activity guided fractionation, two prenylated acetophenones, crassipetalonol A (1) and crassipetalone A (2), were isolated. Their structures were determined mainly by NMR and MS spectroscopic analyses. This is the first record of the isolation and structural characterisation of secondary metabolites from the species A. crassipetala. Their antibacterial and cytotoxic assessments indicated that the known compound (2) had more potent antibacterial activity than the antibiotic chloramphenicol, while the new compound (1) showed moderate cytotoxicity.

Details

Title: Potent Antibacterial Prenylated Acetophenones from the Australian Endemic Plant Acronychia crassipetala
Authors: Trong D Tran (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Malin A Olsson (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
David J McMillan (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
Jason K Cullen (Author) - QIMR Berghofer Medical Research Institute
Peter G Parsons (Author) - QIMR Berghofer Medical Research Institute
Paul W Reddell (Author) - EcoBiotics Ltd.
Steven M Ogbourne (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Publication details: Antibiotics, Vol.9(8), pp.1-9
Publisher: MDPI AG
Date published: 2020
DOI: 10.3390/antibiotics9080487
ISSN: 2079-6382
PMID: 32781771; PMC7460405
Copyright note: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99482301302621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Infectious Diseases; Pharmacology & Pharmacy

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