Post-treatment levels of plasma 25- and 1,25-dihydroxy vitamin D and mortality in men with aggressive prostate cancer

Visalini Nair-Shalliker; Albert Bang; Sam Egger; Mark Clements; Robert A Gardiner; Anne Kricker; Markus J Seibel; Suzanne K Chambers; Michael G Kimlin; Bruce K Armstrong; David P Smith

doi:10.1038/s41598-020-62182-w

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Post-treatment levels of plasma 25- and 1,25-dihydroxy vitamin D and mortality in men with aggressive prostate cancer

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Post-treatment levels of plasma 25- and 1,25-dihydroxy vitamin D and mortality in men with aggressive prostate cancer

Visalini Nair-Shalliker, Albert Bang, Sam Egger, Mark Clements, Robert A Gardiner, Anne Kricker, Markus J Seibel, Suzanne K Chambers, Michael G Kimlin, Bruce K Armstrong, …

Scientific Reports, Vol.10, 7736

2020

DOI: https://doi.org/10.1038/s41598-020-62182-w

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Abstract

Vitamin D may reduce mortality from prostate cancer (PC). We examined the associations of post-treatment plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations with PC mortality. Participants were PC cases from the New South Wales Prostate Cancer Care. All contactable and consenting participants, at 4.9 to 8.6 years after diagnosis, were interviewed and had plasma 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) measured in blood specimens. Cox regression allowing for left-truncation was used to calculate adjusted mortality hazards ratios (HR) and 95% confidence intervals (95% CI) for all-cause and PC-specific mortality in relation to vitamin D levels and other potentially-predictive variables. Of the participants (n= 111; 75.9% response rate), there were 198 deaths from any cause and 41 from PC in the study period. Plasma 25(OH)D was not associated with all-cause or PC-specific mortality (p-values > 0.10). Plasma 1,25(OH)2D was inversely associated with all-cause mortality (HR for highest relative to lowest quartile = 0.45; 95% CI: 0.29-0.69), and PC-specific mortality (HR = 0.40; 95% CI: 0.14-1.19). These associations were apparent only in men with aggressive PC: all-cause mortality HR = 0.28 (95% CI: 0.15-0.52; p-interaction= 0.07) and PC-specific mortality HR = 0.26 (95% CI: 0.07-1.00). Time spent outdoors was also associated with lower all-cause (HR for 4th relative to 1st exposure quartile = 0.42; 95% CI: 0.24-0.75) and PC-specific (HR = 0.48; 95% CI: 0.14-1.64) mortality, although the 95% CI for the latter was wide. The inverse association between post-treatment plasma 1,25(OH)2D levels and all-cause and PC-specific mortality in men with aggressive PC, suggest a possible beneficial effect of vitamin D supplementation in these men.

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Title: Post-treatment levels of plasma 25- and 1,25-dihydroxy vitamin D and mortality in men with aggressive prostate cancer
Authors: Visalini Nair-Shalliker (Author) - University of Sydney
Albert Bang (Author) - Cancer Council NSW
Sam Egger (Author) - Cancer Council NSW
Mark Clements (Author) - Karolinska Institute, Sweden
Robert A Gardiner (Author) - University of Queensland
Anne Kricker (Author) - University of Sydney
Markus J Seibel (Author) - University of Queensland
Suzanne K Chambers (Author) - University of Technology Sydney
Michael G Kimlin (Author) - University of the Sunshine Coast
Bruce K Armstrong (Author) - University of Western Australia
David P Smith (Author) - University of Sydney
Publication details: Scientific Reports, Vol.10, 7736
Publisher: Nature Publishing Group
Date published: 2020
DOI: 10.1038/s41598-020-62182-w
ISSN: 2045-2322
Copyright note: Copyright © The Author(s) 2020 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99450965502621
Output Type: Journal article

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