Possible therapeutic implication of PD-L1/PD-1 axis in endometrial cancer

Jiezhong Chen; Renfu Shao; Chen Chen

doi:10.5430/jst.v5n1p10

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Possible therapeutic implication of PD-L1/PD-1 axis in endometrial cancer

Journal article

Open access

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Possible therapeutic implication of PD-L1/PD-1 axis in endometrial cancer

Jiezhong Chen, Renfu Shao and Chen Chen

Journal of Solid Tumors, Vol.5(1), pp.10-17

2015

DOI: https://doi.org/10.5430/jst.v5n1p10

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Abstract

Oncology and Carcinogenesis

immune escape ability

IFN-gamma

hypoxia

Shp2/PTEN/PI3K/Akt pathway

Endometrial cancer (EC) is a common reproductive system cancer in females and one of the leading causes for cancer-related deaths in women, ranked only after ovarian and cervical cancers. It is classified into two types with type I having better prognosis. At present, surgical removal is the major approach for the treatment of the disease. For those with metastasized cancer, chemotherapy, hormone therapy and radiotherapy are applied. However, the therapeutic efficacy is unsatisfactory and toxicity is severe. Recently, immune system has been recognized as an important factor in both cancer development and treatment. Immunotherapy against PD-1 has been shown to be effective with low side-effects in many cancers. This opens a novel approach for EC treatment as EC has been shown to have increased PD-L1/PD-1 axis. In this review, we summarize the most recent progress in PD-L1/PD-1 axis and prospect that anti PD-L1/PD-1 may be an effective approach for EC treatment.

Details

Title: Possible therapeutic implication of PD-L1/PD-1 axis in endometrial cancer
Authors: Jiezhong Chen (Author) - University of Queensland
Renfu Shao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Chen Chen (Author) - University of Queensland
Publication details: Journal of Solid Tumors, Vol.5(1), pp.10-17
Publisher: Sciedu Press
Date published: 2015
DOI: 10.5430/jst.v5n1p10
ISSN: 1925-4067; 1925-4067
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99449385102621
Output Type: Journal article
Research Statement: false

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