Journal article
Possible therapeutic implication of PD-L1/PD-1 axis in endometrial cancer
Journal of Solid Tumors, Vol.5(1), pp.10-17
2015
Abstract
Endometrial cancer (EC) is a common reproductive system cancer in females and one of the leading causes for cancer-related deaths in women, ranked only after ovarian and cervical cancers. It is classified into two types with type I having better prognosis. At present, surgical removal is the major approach for the treatment of the disease. For those with metastasized cancer, chemotherapy, hormone therapy and radiotherapy are applied. However, the therapeutic efficacy is unsatisfactory and toxicity is severe. Recently, immune system has been recognized as an important factor in both cancer development and treatment. Immunotherapy against PD-1 has been shown to be effective with low side-effects in many cancers. This opens a novel approach for EC treatment as EC has been shown to have increased PD-L1/PD-1 axis. In this review, we summarize the most recent progress in PD-L1/PD-1 axis and prospect that anti PD-L1/PD-1 may be an effective approach for EC treatment.
Details
- Title
- Possible therapeutic implication of PD-L1/PD-1 axis in endometrial cancer
- Authors
- Jiezhong Chen (Author) - University of QueenslandRenfu Shao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringChen Chen (Author) - University of Queensland
- Publication details
- Journal of Solid Tumors, Vol.5(1), pp.10-17
- Publisher
- Sciedu Press
- Date published
- 2015
- DOI
- 10.5430/jst.v5n1p10
- ISSN
- 1925-4067
- Copyright note
- Copyright © 2015 The Authors. Reproduced here with kind permission of the author.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99449385102621
- Output Type
- Journal article
Metrics
140 File views/ downloads
830 Record Views