Possible genetic predisposition to lymphedema after breast cancer

B Newman; Felicity Lose; M A Kedda; M Francois; K Ferguson; M Janda; P Yates; A B Spurdle; S C Hayes

doi:10.1089/lrb.2011.0024

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Possible genetic predisposition to lymphedema after breast cancer

Journal article

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Possible genetic predisposition to lymphedema after breast cancer

B Newman, Felicity Lose, M A Kedda, M Francois, K Ferguson, M Janda, P Yates, A B Spurdle and S C Hayes

Lymphatic Research and Biology, Vol.10(1), pp.2-13

2012

DOI: https://doi.org/10.1089/lrb.2011.0024

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Abstract

Background: Known risk factors for secondary lymphedema only partially explain who develops lymphedema following cancer, suggesting that inherited genetic susceptibility may influence risk. Moreover, identification of molecular signatures could facilitate lymphedema risk prediction prior to surgery or lead to effective drug therapies for prevention or treatment. Recent advances in the molecular biology underlying development of the lymphatic system and related congenital disorders implicate a number of potential candidate genes to explore in relation to secondary lymphedema. Methods and Results: We undertook a nested case-control study, with participants who had developed lymphedema after surgical intervention within the first 18 months of their breast cancer diagnosis serving as cases (n=22) and those without lymphedema serving as controls (n=98), identified from a prospective, population-based, cohort study in Queensland, Australia. TagSNPs that covered all known genetic variation in the genes SOX18, VEGFC, VEGFD, VEGFR2, VEGFR3, RORC, FOXC2, LYVE1, ADM, and PROX1 were selected for genotyping. Multiple SNPs within three receptor genes, VEGFR2, VEGFR3, and RORC, were associated with lymphedema defined by statistical significance (p<0.05) or extreme risk estimates (OR <0.5 or >2.0). Conclusions: These provocative, albeit preliminary, findings regarding possible genetic predisposition to secondary lymphedema following breast cancer treatment warrant further attention for potential replication using larger datasets. © Copyright 2012, Mary Ann Liebert, Inc.

Details

Title: Possible genetic predisposition to lymphedema after breast cancer
Authors: B Newman (Author) - Queensland University of Technology
Felicity Lose (Author) - Queensland Institute of Medical Research
M A Kedda (Author) - Queensland University of Technology
M Francois (Author) - University of Queensland
K Ferguson (Author) - Queensland Institute of Medical Research
M Janda (Author) - Queensland University of Technology
P Yates (Author) - Queensland University of Technology
A B Spurdle (Author) - Queensland Institute of Medical Research
S C Hayes (Author) - Queensland University of Technology
Publication details: Lymphatic Research and Biology, Vol.10(1), pp.2-13
Publisher: Mary Ann Liebert, Inc. Publishers
Date published: 2012
DOI: 10.1089/lrb.2011.0024
ISSN: 1539-6851
Organisation Unit: University of the Sunshine Coast, Queensland; Office of Research
Language: English
Record Identifier: 99450519102621
Output Type: Journal article

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Web Of Science research areas: Medicine, Research & Experimental; Physiology

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