Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus

D Crispim; N J R Fagundes; K G Dos Santos; J Rheinheimer; A P Bouças; B M De Souza; G S MacEdo; L B Leiria; J L Gross; L H Canani

doi:10.1111/j.1365-2265.2009.03684.x

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Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus

Journal article

Peer reviewed

Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus

D Crispim, N J R Fagundes, K G Dos Santos, J Rheinheimer, A P Bouças, B M De Souza, G S MacEdo, L B Leiria, J L Gross and L H Canani

Clinical Endocrinology, Vol.72(5), pp.612-619

2010

DOI: https://doi.org/10.1111/j.1365-2265.2009.03684.x

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Abstract

Background and objective Uncoupling protein 2 (UCP2) plays a role in controlling reactive oxygen species (ROS) production by mitochondria. As ROS overproduction is related to diabetic retinopathy (DR), UCP2 gene polymorphisms might be involved in the development of this complication. We investigated whether the -866G/A (rs659366), Ala55Val (rs660339) and 45 bp insertion/deletion (Ins/Del) polymorphisms in the UCP2 gene might be associated with proliferative DR (PDR). Design and methods In this case-control study, we analysed 501 type 2 diabetic patients (242 patients with PDR and 259 subjects without any degree of DR) and 196 type 1 diabetic patients (85 cases with PDR and 111 without DR). Haplotypes constructed from the combination of the three UCP2 polymorphisms were inferred using a Bayesian statistical method. Results In the type 2 diabetic group, multivariate analyses confirmed that the haplotype [A Val Ins] was an independent risk factor for PDR when present in one [adjusted odds ratio (aOR) = 2.12; P = 0.006], at least one (aOR = 2.75; P = 0.00001), or two copies (aOR = 5.30; P = 0.00001), suggesting an additive model of inheritance. Nevertheless, in type 1 diabetic patients, the association of this haplotype with PDR was confirmed only when it was present in at least one (aOR = 2.68; P = 0.014) or two copies (aOR = 6.02; P = 0.005). Conclusions The haplotype [A Val Ins] seems to be an important risk factor associated with PDR in both type 2 and 1 diabetic groups.

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Title: Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus
Authors: D Crispim (Author) - Hospital de Clı´nicas de Porto Alegre, Brazil
N J R Fagundes (Author) - Federal University of Rio Grande do Sul, Brazil
K G Dos Santos (Author) - Lutheran University of Brazil, Brazil
J Rheinheimer (Author) - Hospital de Clı´nicas de Porto Alegre, Brazil
A P Bouças (Author) - Hospital de Clı´nicas de Porto Alegre, Brazil
B M De Souza (Author) - Hospital de Clı´nicas de Porto Alegre, Brazil
G S MacEdo (Author) - Hospital de Clı´nicas de Porto Alegre, Brazil
L B Leiria (Author) - Hospital de Clı´nicas de Porto Alegre, Brazil
J L Gross (Author) - Hospital de Clı´nicas de Porto Alegre, Brazil
L H Canani (Author) - Hospital de Clı´nicas de Porto Alegre, Brazil
Publication details: Clinical Endocrinology, Vol.72(5), pp.612-619
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2010
DOI: 10.1111/j.1365-2265.2009.03684.x
ISSN: 0300-0664; 0300-0664
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451423102621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Endocrinology & Metabolism

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