Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications

Hossein Adelnia; Huong D N Tran; Peter James Little; Idriss Blakey; Hang T Ta

doi:10.1021/acsbiomaterials.1c00150

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Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications

Journal article

Peer reviewed

Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications

Hossein Adelnia, Huong D N Tran, Peter James Little, Idriss Blakey and Hang T Ta

ACS Biomaterials Science & Engineering, Vol.7(6), pp.2083-2105

2021

DOI: https://doi.org/10.1021/acsbiomaterials.1c00150

PMID: 33797239

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Abstract

poly(aspartic acid)

poly(succinimide)

synthesis and characterizations

biodegradation

biomedical applications

Poly(aspartic acid) (PASP) is an anionic polypeptide that is a highly versatile, biocompatible, and biodegradable polymer that fulfils key requirements for use in a wide variety of biomedical applications. The derivatives of PASP can be readily tailored via the amine-reactive precursor, poly(succinimide) (PSI), which opens up a large window of opportunity for the design and development of novel biomaterials. PASP also has a strong affinity with calcium ions, resulting in complexation, which has been exploited for bone targeting and biomineralization. In addition, recent studies have further verified the biocompatibility and biodegradability of PASP-based polymers, which is attributed to their protein-like structure. In light of growing interest in PASP and its derivatives, this paper presents a comprehensive review on their synthesis, characterization, modification, biodegradation, biocompatibility, and applications in biomedical areas.

Details

Title: Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications
Authors: Hossein Adelnia (Author) - The University of Queensland
Huong D N Tran (Author) - The University of Queensland
Peter James Little (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Idriss Blakey (Author) - The University of Queensland
Hang T Ta (Author) - Griffith University
Publication details: ACS Biomaterials Science & Engineering, Vol.7(6), pp.2083-2105
Publisher: American Chemical Society
Date published: 2021
DOI: 10.1021/acsbiomaterials.1c00150
ISSN: 2373-9878
PMID: 33797239
Grants: Bifunctionalised Contrast Nanoparticles for Simultaneous Diagnosis and Treatment of Thrombosis, Vulnerable Plaques and Inflammation, 1037310, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Innovative Reversible Hemostatic Nanomaterial for Emergency Treatment of Internal Bleeding, 1182347, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Developing smart nanomedicine to enable advanced diagnosis and stimuli-responsive treatment for atherosclerosis and thrombosis, 2002827, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Grant note: Heart Foundation (HTT: 102761), and the University of Queensland (HA, HDNT: Research Training Scholarship).
Organisation Unit: School of Health; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99522207002621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Materials Science, Biomaterials