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Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery1.59 MB
Published VersionCC BY V4.0, Open Access
Journal article
Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery
Cell Death & Disease, Vol.9(12), pp.1-13
2018
PMCID: PMC6242930
PMID: 30455461
Abstract
Preeclampsia is a devastating pregnancy disorder. Severity varies widely, and while severe preeclampsia often requires pre-term delivery, women with mild preeclampsia may reach term with minor interventions. The mechanisms that mediate disease severity are poorly understood, but may include adaptive processes by the placenta. We aimed to establish whether in pregnancies that reached term and those that delivered pre-term, the placental response to preeclampsia was intrinsically different, and explore potential adaptive mechanisms. Hydrogen peroxide production and antioxidant activity were increased in term preeclamptic placentae, whereas pre-term preeclamptic placentae had reduced hydrogen peroxide production and reduced function of the antioxidant system superoxide dismutase compared to control placentae. Markers of mitochondrial fission/fusion, apoptosis and the expression level of mitochondrial complexes were differentially disrupted in term compared to pre-term preeclamptic placentae. Mitochondrial respiration and content were increased in term preeclamptic placentae, but mitochondria had a lower respiratory reserve capacity. Mitochondrial respiration and hydrogen peroxide production were increased in healthy term placentae after in vitro hypoxia/reoxygenation. Placentae from preeclamptic pregnancies that reached term showed multiple adaptions that were not present in pre-term preeclamptic placentae. Increased antioxidant activity, and expression of markers of mitochondrial fusion and apoptotic suppression, may relate to salvaging damaged mitochondria. Increased mitochondrial respiration may allow ongoing tissue function even with reduced respiratory efficiency in term preeclamptic pregnancies. Response after in vitro hypoxia/reoxygenation suggests that disruption of oxygen supply is key to placental mitochondrial adaptations. Reactive oxygen species signal ling in term preeclamptic placentae may be at a level to trigger compensatory antioxidant and mitochondrial responses, allowing tissue level maintenance of function when there is organelle level dysfunction.
Details
- Title
- Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery
- Authors
- Olivia J. Holland (Corresponding Author) - Griffith UniversityJames S. M. Cuffe (Author) - Griffith UniversityMarloes Dekker Nitert (Author) - The University of QueenslandLeonie Callaway (Author) - Royal Brisbane and Women's HospitalKeith A. Kwan Cheung (Author) - Griffith UniversityFilip Radenkovic (Author) - Griffith UniversityAnthony V. Perkins (Author) - Griffith University
- Publication details
- Cell Death & Disease, Vol.9(12), pp.1-13
- Publisher
- Nature Publishing Group
- Date published
- 2018
- DOI
- 10.1038/s41419-018-1190-9
- ISSN
- 2041-4889
- PMID
- 30455461; PMC6242930
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Grant note
- APP569693 / National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia Gold Coast Hospital Foundation
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685295202621
- Output Type
- Journal article
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