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Published VersionCC BY V4.0, Open Access
Journal article
Placenta-Specific Transcripts Containing Androgen Response Elements Are Altered In Silico by Male Growth Outcomes
International Journal of Molecular Sciences, Vol.25(3), pp.1-13
2024
Abstract
A birthweight centile (BWC) below the 25th is associated with an elevated risk of adverse perinatal outcomes, particularly among males. This male vulnerability may stem from alterations in placenta-specific androgen signalling, a signalling axis that involves the androgen receptor (AR)-mediated regulation of target genes containing androgen response elements (AREs). In this study, we examined global and ARE-specific transcriptomic signatures in term male placentae (≥37 weeks of gestation) across BWC subcategories (<10th, 10th–30th, >30th) using RNA-seq and gene set enrichment analysis. ARE-containing transcripts in placentae with BWCs below the 10th percentile were upregulated compared to those in the 10th–30th and >30th percentiles, which coincided with the enrichment of gene sets related to hypoxia and the suppression of gene sets associated with mitochondrial function. In the absence of ARE-containing transcripts in silico, <10th and 10th–30th BWC subcategory placentae upregulated gene sets involved in vasculature development, immune function, and cell adhesion when compared to those in the >30th BWC subcategory. Collectively, our in silico findings suggest that changes in the expression of ARE-containing transcripts in male placentae may contribute to impaired placental vasculature and therefore result in reduced fetal growth outcomes.
Details
- Title
- Placenta-Specific Transcripts Containing Androgen Response Elements Are Altered In Silico by Male Growth Outcomes
- Authors
- Ashley S. Meakin (Corresponding Author) - University of South AustraliaMelanie Smith (Author) - Flinders UniversityJanna L. Morrison (Author) - University of South AustraliaClaire T. Roberts (Author) - Flinders UniversityMartha Lappas (Author) - The University of MelbourneStacey J. Ellery (Author) - Monash UniversityOlivia Holland (Author) - Griffith UniversityAnthony Perkins (Author) - University of the Sunshine Coast, Queensland, School of HealthSharon A. McCracken (Author) - The University of SydneyVicki Flenady (Author) - The University of QueenslandVicki L. Clifton (Corresponding Author) - The University of Queensland
- Publication details
- International Journal of Molecular Sciences, Vol.25(3), pp.1-13
- Publisher
- MDPI AG
- Date published
- 2024
- DOI
- 10.3390/ijms25031688
- ISSN
- 1422-0067; 1661-6596
- Copyright note
- © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Data Availability
- The data generated and analysed during this study are available from the corresponding author on reasonable request.
- Organisation Unit
- School of Health
- Language
- English
- Record Identifier
- 99997698902621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary
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