Pineal volume and evening melatonin in young people with affective disorders

Joanne S Carpenter; Amy C Abelmann; Sean N Hatton; Rebecca Robillard; Daniel F Hermens; Maxwell Bennett; Jim Lagopoulos; Ian B Hickie

doi:10.1007/s11682-016-9650-2

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Pineal volume and evening melatonin in young people with affective disorders

Journal article

Peer reviewed

Pineal volume and evening melatonin in young people with affective disorders

Joanne S Carpenter, Amy C Abelmann, Sean N Hatton, Rebecca Robillard, Daniel F Hermens, Maxwell Bennett, Jim Lagopoulos and Ian B Hickie

Brain Imaging and Behavior, Vol.11(6), pp.1741-1750

2017

DOI: https://doi.org/10.1007/s11682-016-9650-2

Appears in UniSC Diversity and Inclusion Research Collection

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Abstract

sleep

circadian

melatonin

pineal gland

affective disorders

MRI

UniSC Diversity Area - Disability and Inclusion

Affective disorders in young people have been associated with disruptions in circadian rhythms, including abnormalities in secretion of the pineal hormone melatonin. Previous research reports relationships between pineal gland volumes, melatonin secretion, and sleep-wake cycles, but the relationship between these factors has not been explored in affective disorders. This study aimed to characterize these factors and explore associations with mood symptoms and functioning in a sample of young people with affective disorders. Pineal volume from magnetic resonance imaging and melatonin assay from evening dim-light saliva collection were evaluated in 50 individuals (15-30 years old; 72 % female) with bipolar, depressive, or anxiety disorders. Actigraphy monitoring was also conducted for approximately two weeks to derive sleep-wake measures. Pineal volume was associated with melatonin secretion across the evening, replicating previous findings in psychiatrically healthy individuals. Pineal volume was smaller in participants in which melatonin onset was not detected. Timing of melatonin secretion was related to sleep timing, but amount of melatonin and pineal volume were not related to any sleep-wake measures. A shorter phase angle between onset of melatonin secretion and sleep onset was associated with longer total sleep time. Lower melatonin levels were associated with poorer social and occupational functioning. Although pineal volume is not directly related to sleep disturbances or symptoms, melatonin may influence both sleep-wake cycles and functioning in the early stages of affective disorder. Causal links remain to be established, however, treatments that target circadian rhythms may be useful in improving functioning in young people with affective disorders.

Details

Title: Pineal volume and evening melatonin in young people with affective disorders
Authors: Joanne S Carpenter (Author) - University of Sydney
Amy C Abelmann (Author) - University of Sydney
Sean N Hatton (Author) - University of Sydney
Rebecca Robillard (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
Maxwell Bennett (Author) - University of Sydney
Jim Lagopoulos (Author) - University of the Sunshine Coast
Ian B Hickie (Author) - University of Sydney
Publication details: Brain Imaging and Behavior, Vol.11(6), pp.1741-1750
Publisher: Springer New York LLC
Date published: 2017
DOI: 10.1007/s11682-016-9650-2
ISSN: 1931-7557
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450932002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neuroimaging

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